Research Progress on the Regulation of Inflammatory Microenvironment of Endometriosis by Chinese Medicine Based on the Theory of"Same Disease of Blood and Water"
10.19378/j.issn.1003-9783.2024.06.019
- VernacularTitle:基于"血水同病"理论探讨中药调控子宫内膜异位症炎症微环境的研究进展
- Author:
Weilin ZHENG
1
;
Zhiyi FU
;
Danting WEN
;
Hao LIU
;
Lixing CAO
Author Information
1. 广东省第二人民医院,广东 广州 510220
- Keywords:
Endometriosis;
inflammatory microenvironment;
macrophage reprogramming;
same disease of blood and water;
intermingling dampness and blood stasis;
biological connotation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(6):928-934
- CountryChina
- Language:Chinese
-
Abstract:
Endometriosis(EMs)is a chronic inflammatory disease.It has been proved that inflammatory microenvironment is the key role in EMs occurance and development.Chinese medicine posits that the theory of"same disease of blood and water",which generally refers to"intermingling dampness and blood stasis",serves as a crucial pathogenesis in EMs.The inflammatory microenvironment is the main manifestation of dampness and blood stasis in EMs,while the insufficiency of vital qi results in endogenous dampness.The stagnation of blood stasis serves as the foundation for the formation of intermingling dampness and blood stasis.Based on contemporary theories in molecular biology,the macrophage-mediated inflammatory microenvironment serves as the foundation for the formation of dampness,while the participation of macrophages in angiogenesis is crucial for the formation of blood stasis.Investigating the intrinsic connection between the inflammatory microenvironment in EMs and the theory of"same disease of blood and water"can contribute to a better understanding of the pathogenesis of EMs from a novel perspective.Remodeling of the inflammatory microenvironment in endometriosis by targeting macrophages may provide a new strategy for EMs treatment.
