Progress of Traditional Chinese Medicine in Regulating PI3K/Akt Signaling Pathway for the Treatment of Rheumatoid Arthritis
10.19378/j.issn.1003-9783.2024.05.018
- VernacularTitle:中医药调控PI3K/Akt信号通路治疗类风湿关节炎的研究进展
- Author:
Weigang CHENG
1
;
Haolin LI
;
Juanjuan YANG
;
Fangmei JIN
;
Lili KAN
;
Pengfei TAO
;
Zhendong WANG
;
Qian BAI
;
Xiaojun SU
;
Haidong WANG
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
- Keywords:
traditional Chinese medicine;
PI3K/Akt signaling pathway;
rheumatoid arthritis;
research progress
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(5):756-764
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is an autoimmune disease with the basic pathological manifestation of synovial inflammation.Symmetric poly-articular pain and swelling are the main symptoms in clinical practice,and even extra-articular manifestations and comorbidities such as interstitial fibrosis and coronary artery disease are triggered,which seriously affect the quality of life of patients.Traditional Chinese medicine(TCM)has achieved good clinical efficacy in the prevention and treatment of RA with the advantages of multi-pathway,multi-target,multi-component,and less toxic side effects,and plays an important role in the treatment of RA.Recently,many studies have demonstrated that Chinese medicine monomers and Chinese herbal compound can control inflammation,reduce angiogenesis,induce apoptosis of synovial fibroblasts,and inhibit their proliferation,invasion and migration by regulating the PI3K/Akt signaling pathway,so as to play a key role in the treatment of RA.For this reason,the article summarizes current knowledge regarding the PI3K/Akt signaling pathway and its role in RA,as well as summarizes the current research progress of TCM in the treatment of RA by regulating the PI3K/Akt signaling pathway.The aim of this review is to provide theoretical bases for the prevention and treatment of RA and the development of new drugs.
