Analysis of brain gray matter volume alterations in adolescents with bipolar disorder
10.3969/j.issn.1673-9701.2024.33.011
- VernacularTitle:青少年双相障碍抑郁发作患者灰质体积分析
- Author:
Shihui HUANG
1
;
Linqi ZHOU
;
Jialing HUANG
;
Yun WU
;
Jian LIN
;
Changchun HU
Author Information
1. 西湖大学医学院附属杭州市第一人民医院放射科,浙江 杭州 310006
- Keywords:
Bipolar Disorder;
Adolescents;
Gray matter volume;
Neuroimaging;
Depressive episodes
- From:
China Modern Doctor
2024;62(33):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the alterations in gray matter volume(GMV)in adolescents with bipolar disorder(BD).Methods 36 BD patients(BD group)and 37 healthy controls(HC group)who underwent magnetic resonance imaging(MRI)for artificial visual inspection in Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University from September 2019 to December 2021 were selected.Structural MRI data were processed by using FreeSurferv6.0.0,and statistical analysis were conducted by using SPSS 26.0 and R language software.Receiver operating characteristic(ROC)curve were employed to assess the diagnostic efficacy of various brain regions.Results Compared to HC group,patients in BD group exhibited significant reductions in GMV in the right superior frontal gyrus,right nucleus accumbens,left insula,right lateral orbitofrontal cortex,and right medial orbitofrontal cortex(P＜0.05).ROC curve analysis indicated that area under the curve(AUC)for the right superior frontal gyrus and right nucleus accumbens were 0.739 and 0.712 respectively,while the combined AUC for multiple brain regions was 0.820.Conclusion Adolescents with BD show significant reductions in GMV in specific brain regions,provide reference for the early identification and pathological mechanism research of BD.
