Correlation between serum human epididymis protein 4 levels and proteinuria in type 2 diabetes patients
10.3969/j.issn.1673-9701.2024.33.001
- VernacularTitle:2型糖尿病患者血清人附睾蛋白4与蛋白尿的相关性研究
- Author:
Chunyan BO
1
;
Shipei ZHANG
;
Jinshen CHU
;
Guohui XUE
;
Fang WAN
;
Junda CAO
;
Keqi CHEN
;
Jing CHEN
;
Xiaofeng LIU
;
Xueli CHEN
Author Information
1. 九江市第一人民医院营养科,江西九江 332000
- Keywords:
Proteinuria;
Human epididymis protein 4;
Type 2 diabetes mellitus;
Diabetic nephropathy
- From:
China Modern Doctor
2024;62(33):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of human epididymis protein 4(HE4)with proteinuria in patients with type 2 diabetes mellitus(T2DM).Methods A total of 147 T2DM patients from January 2020 to July 2023 in Jiujiang NO.l People's Hospital were enrolled in observation group.According to the severity of proteinuria,observation group was divided into three groups:Normal albuminuria group(101 cases),microalbuminuria group(25 cases),and massive albuminuria group(21 cases).50 healthy examinees with gender and age matching during the same period were selected as control group.HE4 levels and clinical indicators in each group were compared and analyzed.Correlation between HE4 and proteinuria was analyzed by using univariate and multivariate linear regression.Results The correlation network diagram reveals that HE4 functions was a pivotal node linking serum albumin,urinary microalbumin,urinary microalbumin-to-creatinine ratio(UACR),and renal function biomarkers.Compared to control group,HE4 levels significantly elevated in observation group(P＜0.01).Both univariate and multivariate linear regression analysis demonstrate a positive correlation between HE4 and UACR.Logistic regression analysis shew that after adjusting for confounding factors including age,gender,estimated glomerular filtration rate(eGFR),albumin(ALB),blood urea nitrogen(BUN),serum creatinine(SCr),uric acid(UA),lactate dehydrogenase(LDH)etc.elevated HE4 levels was a risk factor for proteinuria(OR=1.110,95％CI:1.005-1.226).Conclusion Elevated HE4 levels in patients with T2DM is positivly correlated with UACR.Increase its level increases the risk of proteinuria in T2DM patients.
