Application value of heparin binding protein,NLR,LMR,and PLR in immune function reconstruction evaluation in HIV/AIDS patients
10.3969/j.issn.1673-9701.2024.32.012
- VernacularTitle:肝素结合蛋白、NLR、LMR及PLR在HIV/AIDS患者免疫功能重建评估中的应用价值
- Author:
Lingyan HE
1
;
Jinchuan SHI
;
Jianghao CHENG
;
Mingli ZHU
Author Information
1. 浙江中医药大学附属杭州西溪医院检验科,浙江 杭州 310023
- Keywords:
Heparin binding protein;
Neutrophil to lymphocyte ratio;
Lymphocyte to monocyte ratio;
Platelet to lymphocyte ratio
- From:
China Modern Doctor
2024;62(32):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of heparin binding protein(HBP),neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),and platelet to lymphocyte ratio(PLR)in the evaluation of immune function reconstruction in human immunodeficiency virus(HIV)infected individuals/acquired immunodeficiency syndrome(AIDS)patients.Methods Collect 138 HIV/AIDS patients from the Outpatient Department of Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University from January 1,to June 30,2023.According to CD4+T lymphocyte counts after antiretroviral treatment,categorize patients into groups with good immune function reconstruction(n=108)and poor immune function reconstruction(n=30).Compare the levels of HBP,NLR,LMR,and PLR between two groups,receiver operating characteristic(ROC)curve was used to evaluate the application value of HBP,NLR,LMR,and PLR in the reconstruction of patient immune function.Results The NLR and PLR of group with good immune function reconstruction was significantly higher than that of group with poor immune function reconstruction(P＜0.05).The LMR of group with good immune function reconstruction were significantly lower than those of group with poor immune function reconstruction(P＜0.05).The HBP between two groups was no significant differences(P＞0.05).LMR had the best efficacy in evaluating whether immune function reconstruction was good in HIV/AIDS patients area under the curve(AUC)=0.803,PLR was the second(AUC)=0.796,NLR was poor(AUC)=0.728.Conclusion NLR,LMR,and PLR are closely related to the immune function of HIV/AIDS patients and can be used as detection indicators to evaluate whether the immune function reconstruction of HIV/AIDS patients is good.
