Relationship between serum magnesium levels and stroke-associated infections in patients with ischemic stroke in the hyperacute phase
10.3969/j.issn.1673-9701.2024.32.011
- VernacularTitle:缺血性卒中超急性期患者血镁水平与卒中相关感染的相关性
- Author:
Rending ZHU
1
;
Liangbing ZHANG
Author Information
1. 安徽医科大学附属安庆第一人民医院神经内科,安徽安庆 246000
- Keywords:
Serum magnesium;
Hyperacute phase;
Ischemic stroke;
Stroke associated infection
- From:
China Modern Doctor
2024;62(32):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential association between serum magnesium levels and stroke-associated infections(SAI)in patients with hyperacute ischemic stroke(IS).Methods A total of 108 patients with hyperacute IS in the Neurology Department of Anqing First People's Hospital of Anhui Medical University from January 2022 to January 2023 were selected.Clinical data such as gender,age,history of hypertension,diabetes,atrial fibrillation,and emergency endovascular treatment during this admission were collected.The National Institutes of Health stroke scale(NIHSS)score at admission,serum magnesium levels within 6 hours of IS onset,and other laboratory indicators within 24 hours of onset were recorded.Patients were divided into SAI group(n=37)and non-SAI group(n=71)based on whether they developed an infection after admission.Differences in clinical data and laboratory indicators between two groups were compared.Multivariate logistic regression analysis was conducted to identify the independent factors influencing the occurrence of SAI in IS patients,and the correlation between serum magnesium and other influencing factors was analyzed.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum magnesium for SAI in IS patients.Results Patients in SAI group were generally older,had higher proportions of atrial fibrillation,were more likely to receive endovascular treatment,had higher NIHSS scores,and higher fasting blood glucose levels(P＜0.05).Serum magnesium levels,lymphocyte counts,and platelet counts were significantly lower in SAI group compared to non-SAI group(P＜0.05).Among the 108 patients,19 had hypomagnesemia.Multivariate Logistic regression analysis showed that serum magnesium,age,and NIHSS scores were independent factors associated with SAI in hyperacute IS patients.Pearson analysis showed that serum magnesium levels in hyperacute IS patients were negatively correlated with NIHSS scores(r=-0.233,P=0.015),but had no correlation with age(P＞0.05).ROC curve analysis showed that the area under the curve for predicting SAI using serum magnesium was 0.674(95％CI:0.567-0.781,P=0.003),with an optimal cutoff value of 0.80 mmol/L,a sensitivity of 48.6％,and a specificity of 78.9％.Conclusion The risk of SAI with hyperacute IS patients with low magnesium lesions is high,and blood and magnesium levels can be used as predictive indicators of SAI for hyperacute IS patients.
