A retrospective analysis of 65 cases of drug-induced liver injury
10.3969/j.issn.1673-9701.2024.31.014
- VernacularTitle:65例药物性肝损伤的回顾性分析
- Author:
Yuwen HUANG
1
;
Yueqiao CHEN
;
Na WANG
;
Yu CHEN
;
Liyi PAN
;
Yanyan ZHANG
Author Information
1. 广西中医药大学研究生院,广西南宁 530200
- Keywords:
Drug-induced liver injury;
Clinical characteristic;
Traditional Chinese medicine treatment
- From:
China Modern Doctor
2024;62(31):60-63,71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of drug-induced liver injury(DILI),and provide reference for early clinical recognition,diagnosis and treatment of DILI.Methods Clinical datas of 65 patients with DILI hospitalized in the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2019 to December 2023 were retrospectively analyzed,and their general conditions,using drugs,distribution type of liver injury,traditional Chinese medicine treatment and outcome were statistically analyzed.Results A total of 65 patients were included,including 27 males and 38 females,with an average age of(46.40±19.19)years old.The majority of patients were 41 to 60 years old.Chinese herbal medicine and Chinese patent medicine accounted for the highest proportion of drugs inducing DILI(30.8％).Hepatocyte injury was the most common type of DILI,with 39 cases.The main clinical manifestations of DILI patients were fatigue,abdominal discomfort,aversion to oil,yellow eyes,yellow urine and so on.In the treatment of traditional Chinese medicine,liquorice root was the most frequently used,with a frequency of 60.7％.After active treatment,59 patients were cured and discharged from hospital.Conclusion Hepatocyte injury is the main type of DILI.Clinical monitoring of hepatotoxicity of traditional Chinese herbal medicine and Chinese patent medicine should be strengthened to reduce the damage to liver caused by adverse drug reactions.
