The predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the type 2 diabetic nephropathy
10.3969/j.issn.1673-9701.2024.30.010
- VernacularTitle:NLR、PLR对2型糖尿病肾病的预测价值
- Author:
Dengyao LIANG
1
;
Shiwei LIU
Author Information
1. 山西白求恩医院山西医学科学院山西医科大学第三医院同济山西医院内分泌科内分泌代谢病山西省重点实验室,山西太原 030032
- Keywords:
Neutrophil-to-lymphocyte ratio;
Platelet-to-lymphocyte ratio;
Diabetic nephropathy;
Type 2 diabetes mellitus
- From:
China Modern Doctor
2024;62(30):51-54,60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with type 2 diabetic nephropathy (T2DN),and to analyze the value of NLR and PLR independent and combined detection in predicting T2DN.Methods A total of 300 patients with type 2 diabetes mellitus from Department of Endocrinology,Shanxi Bethune Hospital from December 2021 to September 2023 were analyzed retrospectively.According to the urinary albumin-creatinin ratio (ACR),patients were divided into the normal albuminuria group (A1 group,n=100),microalbuminuria group (A2 group,n=100) and the macroalbuminuria group (A3 group,n=100).The clinical and biochemical data (blood routine,blood biochemistry,glycosylated hemoglobin A1c,etc) were collected by fasting blood.Results NLR and PLR of patients in A3 group and A2 group were higher than those in A1 group ( P<0.05).NLR and PLR of patients in A3 group were higher than those in A2 group (P<0.05).Logistic regression analysis displayed that NLR (OR=1.702,95％CI:1.290-2.247,P<0.001]and PLR (OR=1.007,95％CI:1.001-1.014,P=0.033) were risk factors for T2DN.According to the analysis of receiver operating characteristic curve,the value of NLR for predicting T2DN was higher than PLR[area under the curve (AUC):0.715 vs.0.655].The cut-off values of NLR and PLR for predicting T2DN were 1.975 and 126.135,the corresponding sensitivity and specificity were 72.0％,64.0％ and 53.0％,74.0％ respectively.When NLR was combined with PLR,the AUC was 0.714,the sensitivity of combined prediction was 68.0％,and the specificity was 68.5％.Conclusion NLR and PLR are both risk factors for T2DN,and both can be used to predict T2DN.NLR has the greatest predict value for T2DN.The combined predictive value of NLR and PLR were not improved compared with NLR alone.
