The expression of OLR1 and its correlation with immune cell invasion and prognosis in ovarian cancer
10.3969/j.issn.1673-9701.2024.30.006
- VernacularTitle:OLR1在卵巢癌中的表达及其与免疫细胞浸润、预后的相关性分析
- Author:
Xinxin ZHANG
1
;
Pu ZHANG
;
Xiangjian ZHANG
;
Xiangyu CHEN
Author Information
1. 温州医科大学附属第二医院 育英儿童医院妇科,浙江温州 325000
- Keywords:
Ovarian cancer;
OLR1;
Immune infiltration;
Prognosis;
Bioinformatics
- From:
China Modern Doctor
2024;62(30):29-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze oxidized low density lipoprotein receptor 1 (OLR1) expression characteristics and its correlation with immune cell infiltration and prognostic outcomes in ovarian cancer by bioinformatics methods.Methods GEPIA2,GeneMANIA,STRING,cBioPortal,LinkedOmics,TIMER 2.0 and TISIDB databases and Kaplan-Meier survivorship curve were used to examine the differential expression of the OLR1 gene between ovarian cancer tissues and normal ovarian tissues and its association with prognosis,and they were used to analyze co-expressed genes and protein-interaction networks of OLR1,the gene mutation status in ovarian cancer,and the correlation between OLR1 expression and tumor immune cell infiltration and immune modulator expression levels.Results The expression of OLR1 was significantly higher in ovarian cancer tissues,and the high expression of OLR1 significantly shortened overall survival (OS),progression-free survival (PFS) and post-progression survival (PPS) (P<0.05).OLR1 expression was positively correlated with infiltration of CD8+T cells,dendritic cells,macrophages,neutrophils,and most immunosuppressants,immunostimulants,and major histocompatibility complex associated molecules.Conclusion The OLR1 gene can serve as a biomarker for the diagnosis,prognosis,and evaluation of immune cell infiltration levels in ovarian cancer.
