Clinical efficacy of meropenem by different infusion therapies in treatment of severe sepsis in children
10.3969/j.issn.1673-9701.2024.29.018
- VernacularTitle:美罗培南不同输注模式对儿童严重脓毒症的疗效观察
- Author:
Yu HAN
1
;
Peisen RUAN
;
Yao ZHENG
;
Yinquan XU
;
Hehe CHEN
Author Information
1. 宁波大学附属妇女儿童医院儿童重症监护中心,浙江宁波 315000
- Keywords:
Meropenem;
Two step infusion therapy;
Severe sepsis;
Pediatric intensive care unit
- From:
China Modern Doctor
2024;62(29):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and clearance rate of pathogens of meropenem by different infusion therapies in treatment of severe sepsis for pediatric patients.Methods Sixty inpatients with serious sepsis from Pediatric Intensive Care Unit,Women and Children's Hospital of Ningbo University were randomly divided into three groups 20 in each.The meropenem was given according to the recommended therapeutic dose.Group A:The micropump was pumped for 0.5h at a rate of 100ml/h.Group B:The micropump was pumped for 3h at a rate of 16.7ml/h.Group C:Half of the menopenen was pumped for 0.5h at a rate of 50ml/h,and the other half was pumped for 2.5h at a rate of 10ml/h.Changes of indexes were compared before and after the treatment to estimate of the clinical effective rate,clearance rate of pathogens and side effects among the groups.Results There were observable improvements in the inflammatory indicators after treatment,such as white cell count,C-reactive protein and procalcitonin,etc.The total effective rate was 60％in group A,75％in group B,and 95％in group C.There were statistically differences among the groups(P＜0.05).Meanwhile,the bacterial clearance rates of the groups were 50％(group A),70％(group B)and 100％(group C),respectively(P＜0.05).The rate of side effect was 20％(group A),15％(group B)and 20％(group C),respectively(P＞0.05).Conclusion It can significantly improve the clinical efficacy and antibacterial efficacy by the two step infusion therapy of meropenem,compared with traditional infusion therapy and extended infusion.
