Expression of PD-L1 and CD8 in HER2 positive breast cancer and its clinicopathological significance
10.3969/j.issn.1673-9701.2024.29.011
- VernacularTitle:PD-L1和CD8在HER2阳性乳腺癌患者中的表达及其与病理参数相关性分析
- Author:
Tiantian ZHAO
1
;
Chao DUAN
;
Xuwen ZHAO
;
Qirong MAN
;
Xiangge WANG
Author Information
1. 山东省滕州市中心人民医院病理科,山东滕州 277500
- Keywords:
Programmed cell death-ligand 1;
Cluster of differentiation 8;
Human epidermal growth factor receptor 2;
Breast cancer;
Prognosis
- From:
China Modern Doctor
2024;62(29):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the role of programmed cell death-ligand l(PD-L1)and cluster of differentiation 8(CD8)in judging the prognosis of human epidermal growth factor receptor 2(HER2)positive breast cancer patients,through evaluating the expression of PD-L1 and CD8 in the tumor microenvironment,and their correlation with clinicopathological data.Methods A total of 65 HER2 positive breast cancer patients were collected admitted to Tengzhou Central People's Hospital in Shandong Province from October 2016 to October 2018,all of whom were women.Theparaffin slices of cancer tissue were labeled with PD-L1 and CD8 using immunohistochemical methods.Collect clinicopathological data of patients,including 7 prognostic parameters,such as age,histological grade,P53,KI-67,estrogen receptor,progesterone receptor and tumor node metastasis classification(TNM)staging.Statistical analysis was conducted to determine whether the expression of PD-L1 and CD8 were correlated with the above clinicopathological data.Results PD-L1 positive rate was 21.5％,the positive expression of PD-L1 was correlated with histological grading and TNM staging,and the difference in results was statistically significant(x2=6.250,P=0.044;x2=13.730,P=0.001);CD8 positive rate was 32.3％,the expression of CD8 cells was correlated with histological grading and TNM staging,and the difference in results was statistically significant(x2=8.023,P=0.018;x2=6.117,P=0.047).Conclusion PD-L1 and CD8 expression are correlated with breast cancer histological grade and TNM stage.PD-L1 and CD8 expression may be important prognostic markers for HER2 positive breast cancer patients.
