CT findings and clinical features of checkpoint inhibitor-related pneumonitis
10.3969/j.issn.1673-9701.2024.29.009
- VernacularTitle:免疫检查点抑制剂相关性肺炎CT表现与临床特点分析
- Author:
Ying LI
1
;
Xiaofei WANG
;
Shengwei LU
;
Danni DONG
;
Jingfeng ZHANG
;
Jianjun ZHENG
Author Information
1. 宁波市第二医院放射科,浙江宁波 315000
- Keywords:
Immune checkpoint inhibitors;
pneumonia;
CT manifestations
- From:
China Modern Doctor
2024;62(29):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the CT manifestations and clinical features of checkpoint inhibitor-related pneumonitis(CIP).Methods Chest CT images and clinical data of 34 patients with CIP in Ningbo No.2 Hospitael were collected to retrospectively analysis.According to the site of tumor occurrence,22 patients were divided into lung cancer group and 12 patients in other malignant tumor group,and the differences in CT manifestations between two groups were compared.Results Cough(70.59％)and dyspnea(52.94％)were the common clinical symptoms.CIP occurred earlier and over a greater time span in lung cancer group 114.5(41.50,281.50)d than in other maligment tumor group 144(55.75,226.25)d.Eosinophil count was significantly higher only in other maligment tumor group(P=0.009).After hormonal therapy 18 patients improved,8 were stable and 8 progressed or even died.CT signs were prevalent in ground glass shadow(70.59％)and solid shadow(76.47％),and the imaging pattern was dominated by organic pneumonia pattern(47.6％),which was not related to type of primary tumor,and some of them could show nodular granulomatous reaction.Compared to lung cancer group,the other maligment tumor group was more likely to exhibit symmetrical infiltration(58.33％)distribution.Conclusion The clinical features of CIP are nonspecific,compared with other patients with primary malignancies,lung cancer patients are more likely to develop CIP,which is difficult to relieve after treatment,and are easy to develop severe disease.
