Correlation between IL-6 and Kim-1 and CIN after PCI for patients with coronary heart disease
10.3969/j.issn.1673-9701.2024.29.001
- VernacularTitle:IL-6、Kim-1与冠心病患者PCI术后CIN的相关性研究
- Author:
Yuedong SUN
1
;
Xinling ZHOU
;
Zilong WANG
;
Luhua YIN
;
Huanyi ZHANG
;
Yun GAO
;
Fazhan ZHOU
Author Information
1. 青岛大学附属泰安市中心医院心内科,山东泰安 271000
- Keywords:
Contrast-induced pnephropathy;
Interleukin-6;
Kidney injury molecule-1;
Percutaneous coronary intervention
- From:
China Modern Doctor
2024;62(29):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of interleukin(IL)-6 and kidney injury molecule(Kim)-1 in the early prediction of contrast-induced pnephropathy(CIN)after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods A total of 730 patients with coronary heart disease who underwent PCI were retrospectively collected,divided into CIN group(n=46)and non-CIN group(n=684),and the medical records of the two groups were compared,and the relationship between Kim-1 and IL-6 of renal injury and CIN was analyzed by binary regression,and the receiver operating characteristic(ROC)curve was used to explore the predictive value of these two markers on CIN after PCI for coronary heart disease.Results There was no significant difference between two groups in terms of preoperative IL-6(P=0.467)and Kim-1(P=0.643),and 48h and 72h after PCI,IL-6 and Kim-1 in CIN group was higher than that in non-CIN group(P＜0.001),and IL-6 and Kim-1 in CIN group was higher than that in before surgery(P＜0.001).48h postoperative IL-6(OR=1.884,P=0.002),48h postoperative Kim-1(OR=1.409,P＜0.001)and 72h postoperative IL-6(OR=1.377,P＜0.001)and 72 hours postoperative Kim-1(OR=1.092,P=0.004)were independent risk factors for CIN.The ROC curve showed that when used as a diagnostic marker for CIN,the area under the curve(AUC)of IL-6(48h),IL-6(72h)were 0.837,0.782,AUC of 48h Kim-1 and 72h Kim-1 were 0.820 and 0.827,respectively.Conclusion IL-6 and Kim-1 are independent risk factors for CIN after PCI for coronary heart disease.IL-6 and Kim-1 were positively correlated with the occurrence of CIN after PCI for coronary heart disease.IL-6 and Kim-1 have good diagnostic sensitivity and specificity for CIN after PCI for coronary heart disease.
