Therapeutic efficacy of Jiawei Liujunzi decoction in treatment of volume overload with peritoneal dialysis
10.3969/j.issn.1673-9701.2024.28.016
- VernacularTitle:加味六君子汤治疗腹膜透析容量超负荷的疗效观察
- Author:
Shuhan YU
1
;
Sha CHEN
;
Qingxia ZHANG
;
Hong PAN
;
Zhijie LIU
Author Information
1. 温州医科大学附属东阳市中医院肾内科,浙江 东阳 322100
- Keywords:
Jiawei Liujunzi decoction;
Volume loading;
Residual renal function;
Continuous ambulatory peritoneal dialysis
- From:
China Modern Doctor
2024;62(28):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Jiawei Liujunzi decoction in improving volume overload and residual renal protection in continuous ambulatory peritoneal dialysis(CAPD)patients with spleen deficiency.Methods A total of 82 patients treated in the Peritoneal Dialysis Center of Dongyang Hospital of Traditional Chinese Medicine of Affiliated to Wenzhou Medical University from July 2022 to April 2023 were selected as study objects.According to random number table method,the patients were divided into control group and treatment group,41 cases in each group.The control group was given basic western medicine treatment,and the treatment group was given supplemented with Jiawei Liujunzi decoction on the basis of control group,and the treatment course was 8 weeks.The percentage of extracellular water to total body water(ECW％),urea clearance index of residual kidney(Kt/V)and brain natriuretic peptide(BNP)of two groups were compared,and safety of the drug was evaluated.Results After treatment,ECW％and BNP in two groups were significantly lower than before treatment(P＜0.05).The urine volume of control group was significantly lower than that before treatment(P＜0.05).After treatment,there were no significant differences in ECW％,BNP,Kt/V and urine volume between two groups(P＞0.05).After treatment,there were no significant differences in alanine aminotransferase,aspartate aminotransferase,albumin,phosphorus,calcium and potassium between two groups(P＞0.05),indicating good safety.After 12 months of follow-up,the survival rate of treatment group was significantly higher than that of control group(P＜0.05).Conclusion Jiawei Liujunzi decoction can improve the volume overload of CAPD patients with spleen deficiency to a certain extent,with good safety,and can improve the long-term survival rate of patients.
