Efficacy of hyperbaric oxygen combined with Sheshang powder in the treatment of venomous snake bite
10.3969/j.issn.1673-9701.2024.28.013
- VernacularTitle:高压氧联用蛇伤散治疗毒蛇咬伤的疗效观察
- Author:
Yuchen SHEN
1
;
Min YANG
;
Chengda YUAN
;
Jing WANG
Author Information
1. 浙江中医药大学附属杭州市中医院皮肤科,浙江 杭州 310007
- Keywords:
Venomous snake bite;
Circulatory toxin;
Hyperbaric oxygen;
Sheshang powder
- From:
China Modern Doctor
2024;62(28):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of hyperbaric oxygen combined with Sheshang powder in the treatment of venomous snake bite.Methods A total of 112 patients with venomous snake bite admitted to Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University from April 2021 to October 2023 were selected,and they were divided into conventional treatment group,conventional treatment+Sheshang powder treatment group,conventional treatment+hyperbaric oxygen treatment group and conventional treatment+hyperbaric oxygen combined with Sheshang powder treatment group according to random number table method,with 28 cases in each group.The difference of circumference between injured limb and healthy limb,visual analogue scale(VAS)score and coagulation function index[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib)]of four groups were compared.Results After treatment,the swelling of injured limbs in four groups gradually decreased over time(P＜0.05).On the third day of treatment,the circumference difference of patients in conventional treatment+hyperbaric oxygen combined with Sheshang powder treatment group was significantly lower than that in conventional treatment group and conventional treatment+Sheshang powder treatment group(P＜0.05).After treatment,PT,APTT and Fib of four groups were better than before treatment(P＜0.05),PT and APTT of patients in conventional treatment+Sheshang powder treatment group were significantly lower than those in conventional treatment group and conventional treatment+hyperbaric oxygen treatment group,and Fib was significantly higher than that in conventional treatment group and conventional treatment+hyperbaric oxygen treatment group(P＜0.05).PT and APTT of patients in conventional treatment+hyperbaric oxygen combined with Sheshang powder treatment group were significantly lower than those in other three groups,and Fib was significantly higher than that in other three groups(P＜0.05).After treatment,the VAS scores of four groups were significantly lower than before treatment(P＜0.05),and there were significant differences in VAS scores among the four groups(P＜0.05).Conclusion Hyperbaric oxygen combined with Sheshang powder can effectively improve the coagulation function of patients bitten by venomous snakes,relieve limb swelling and pain.
