Identification of immune-related prognostic molecular markers of breast cancer
10.3969/j.issn.1673-9701.2024.28.011
- VernacularTitle:乳腺癌免疫相关预后分子标志物的鉴定
- Author:
Biying SONG
1
;
Yichao WANG
;
Qianyi ZHONG
;
Chunxue LI
;
Shihao LI
Author Information
1. 台州市中心医院(台州学院附属医院)检验科,浙江台州 318000
- Keywords:
Breast cancer;
Immune;
S100P;
TSLP
- From:
China Modern Doctor
2024;62(28):52-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression characteristics of S100 calcium binding protein P(Sl00P)and thymic stromal lymphopoietin(TSLP)in patients with breast cancer and their relationship with prognosis.Methods GEPIA database and bc-GenExMiner v4.3 were used to analyze the expression levels of S100P and TSLP in breast cancer tissues,and Kaplan-Meier Plotter was used to analyze effects of S100P and TSLP on patient prognosis.The protein interaction network analysis of S100P and TSLP were carried out by using STRING database.The co-expressed genes of S100P and TSLP were analyzed using Linked Omics database,and the role of S100P and TSLP co-expressed genes in related biological processes and signaling pathways were evaluated by gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.The correlation between S100P and TSLP and breast cancer immunoinfiltration was analyzed by TIMER.Results The expression of S100P in breast cancer patients was significantly higher than that in normal population,and the expression of TSLP was significantly lower than that in normal population(P＜0.05).The overall survival,disease-free survival and distant metastasis-free survival of patients with high S100P expression were significantly shorter than those of patients with low S100P expression(P＜0.05).The distant metastasis-free survival of patients with high expression of TSLP was significantly longer than that of patients with low expression of TSLP(P＜0.05).The results of protein interaction showed that S100P had a strong interaction with interleukin-11,and TSLP had a strong interaction with interleukin family proteins.The co-expressed genes of S100P and TSLP were mainly responsible for biological functions such as DNA replication and immune function.TSLP was correlated with breast cancer immune cell infiltration.Conclusion S100P and TSLP can be used as biomarkers to predict the prognosis of breast cancer,and they can also help to evaluate the tumor immunoinfiltration in breast cancer patients,and TSLP could provide theoretical basis for predicting the prognosis and tumor immunotherapy in breast cancer patients.
