Prognostic value of NLR and LMR in patients with ischemic stroke treated with thrombolysis
10.3969/j.issn.1673-9701.2024.28.009
- VernacularTitle:NLR、LMR对缺血性脑卒中溶栓患者预后的预测价值
- Author:
Tianjun WU
1
,
2
;
Runxiu ZHU
Author Information
1. 包头医学院研究生学院,内蒙古包头 014040
2. 内蒙古自治区人民医院神经内科,内蒙古呼和浩特 010017
- Keywords:
Acute ischemic stroke;
Neutrophil;
Lymphocyte;
Monocyte;
Intravenous thrombolysis;
Predictive value
- From:
China Modern Doctor
2024;62(28):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of neutrophil to lymphocyte ratio(NLR)and lymphocyte to monocyte ratio(LMR)before thrombolysis in patients with acute ischemic stroke(AIS)who received intravenous thrombolysis.Methods The clinical data of 196 AIS patients who received intravenous thrombolysis in Inner Mongolia Autonomous Region People's Hospital from January to June 2023 were analyzed retrospectively.According to the modified Rankin scale(mRS)score 90 days after thrombolysis,the patients were divided into improvement group(mRS score ≤2 points)and non-improvement group(mRS score＞2 points).The clinical data of patients were collected.Binary Logistic regression analysis was used to explore the independent factors affecting the prognosis of patients.Receiver operating characteristic curve was drawn to analyze the predictive value of NLR and LMR.Results The age,proportion of diabetes history and antiplatelet drug history in improvement group were significantly lower than those in non-improvement group(P＜0.05).The D-dimer,neutrophil absolute value,C-reactive protein and NLR in improvement group were significantly lower than those in non-improvement group,while lymphocyte absolute value and LMR in improvement group were significantly higher than those in non-improvement group(P＜0.05).Binary Logistic regression analysis showed that elevated NLR,diabetes history,and antiplatelet drug history were independent risk factors affecting the prognosis of AIS patients(P＜0.05).The area under the curve(AUC)of NLR,diabetes history,and antiplatelet drug history predicted the prognosis of AIS patients was 0.682,0.616,and 0.563,respectively.The AUC of combined prediction of these three indexes was 0.742,with a sensitivity of 66.9％and a specificity of 75.0％.Conclusion NLR,diabetes history,and antiplatelet drug history have predictive value for AIS patients.
