Predictive value of lactate/albumin and C-reactive protein for 90-day mortality risk in patients with sepsis
10.3969/j.issn.1673-9701.2024.27.001
- VernacularTitle:乳酸/白蛋白和C反应蛋白对脓毒症患者90d死亡风险的预测价值
- Author:
Xiaolu DU
1
;
Yasheng ZHAN
;
Meijiao XIANG
Author Information
1. 金华市人民医院综合重症医学科,浙江金华 321000
- Keywords:
Lactate/albumin;
C-reactive protein;
Sepsis;
Mortality risk;
Predictive value
- From:
China Modern Doctor
2024;62(27):1-5,30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of lactate/albumin(L/A)and C-reactive protein(CRP)for 90-day mortality risk in patients with sepsis.Methods Clinical data from 125 patients diagnosed with sepsis in the Comprehensive Intensive Care Unit,Jinhua People's Hospital from February 2021 to February 2024 retrospectively were collected.According to 90-day death or not of patients,they were divided into death group(n=61)and survival group(n=64).Independent risk factors for 90-day mortality in patients with sepsis were analyzed by using multivariate Logistic regression.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of L/A,CRP,and L/A combined CRP for 90-day mortality in patients with sepsis.At the same time,subgroup analysis of patients was performed according to the best cut-off value,and Kaplan-Meier survival curves were drawn.Results Multivariate Logistic regression analysis showed that high CRP(OR=1.009,95％CI:1.003-1.015,P=0.006),high L/A(OR=1.449,95％CI:1.050-2.000,P=0.024),and concurrent acute kidney injury(OR=2.890,95％CI:1.198-6.975,P=0.018)were independent risk factors for 90-day mortality in patients with sepsis.Area under the curve(AUC)for predicting 90-day mortality in patients with sepsis by using CRP,L/A,and L/A combined with CRP were 0.645,0.612 and 0.708 respectively.Subgroup analysis showed that 90-day mortality of patients with sepsis in L/A＞1.41 group was significantly higher than that in L/A≤1.41 group(P=0.001),and 90-day mortality of patients with sepsis in CRP＞93.29mg/L group was significantly higher than that in CRP≤93.29mg/L group(P=0.001),which was consistent with the analysis results of Kaplan-Meier survival curve.Conclusion Both L/A and CRP have certain predictive value for 90-day prognosis of patients with sepsis,and their combined predictive effect is better.
