Association of serum β2-microglobulin levels with post-stroke cognitive impairment
10.3969/j.issn.1673-9701.2024.26.008
- VernacularTitle:血清β2微球蛋白与缺血性脑卒中后认知功能障碍的关系研究
- Author:
Xiaoli CHEN
1
;
Senxiang WU
;
Ruru YU
;
Luping FAN
;
Xueyan HUANG
Author Information
1. 温州市人民医院康复科,浙江温州 325000
- Keywords:
Serum β2-microglobulin;
Ischemic stroke;
Cognitive impairment
- From:
China Modern Doctor
2024;62(26):33-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether an association existed between elevated serum β2-microglobulin levels and post stroke cognitive impairment(PSCI).Methods A total of 140 patients with ischemic stroke in Wenzhou People's Hospital during December 2022 to December 2023 were prospectively were enrolled including 73 patients in the PSCI group and 67 patients in the non-post stroke cognitive impairment(PSNCI)group.Serum β2-microglobulin and other biochemical indicators were measured within 24 hours after admission.PSCI was assessed using the mini-mental state examination(MMSE)score with a threshold of≥27 points serving as the diagnostic criterion.Results The age,National Institutes of Health Stroke Scale(NIHSS)score at admission,proportion of low education level,proportion of multiple or large area infarction and serum β2-microglobulin level in the PSCI group were higher than those in the PSNCI group.Multivariate Logistic regression analysis showed that age,NIHSS score at admission,multiple or large area infarction and serum β2-microglobulin level were risk factors for PSCI,and education level was a protective factor for PSCI.Conclusion The increase of β2-microglobulin level is a risk factor for cognitive impairment after ischemic stroke.The detection of β2-microglobulin level in stroke patients may realize the early detection of PSCI.
