Comparative study on the efficacy of recombinant interferon-α-2b and ipratropium bromide in the treatment of pediatric bronchiolitis
10.3969/j.issn.1673-9701.2024.25.018
- VernacularTitle:重组α干扰素-2b与异丙托溴铵治疗小儿毛细支气管炎的疗效对比研究
- Author:
Miao CHEN
1
;
Xiaojuan SHEN
;
Wenyan PAN
Author Information
1. 湖州师范学院附属中心医院输液室,浙江湖州 313000
- Keywords:
Recombinant interferon-α-2b;
Ipratropium bromide;
Bronchiolitis;
Atomization inhalation;
Immune function;
Adverse reaction
- From:
China Modern Doctor
2024;62(25):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of recombinant interferon(IFN)-α-2b and ipratropium bromide atomized inhalation in pediatric bronchiolitis.Methods A total of 112 children with bronchiolitis diagnosed and treated in Huzhou Central Hospital from April 2020 to August 2022 were selected and divided into control group and observation group according to envelope method,with 56 cases in each group.The control group was treated with atomization inhalation of ipratropium bromide,and the observation group was treated with atomization inhalation of recombinant IFN-α-2b.Both groups completed 7 days of treatment,and the lung function,interferon-γ(IFN-γ),interleukin-10(IL-10),immune function and adverse reaction were compared between two groups.Results After 7 days of intervention,the disappearance time of wheezing,cough,lung moist rales and sputum sounds in observation group were significantly shorter than those in control group(P＜0.05).The tidal volume(TV),peak tidal expiratory flow(PTEF),ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE),IFN-γ and IL-10 in both groups were significantly higher than those before intervention(P＜0.05).TV,PTEF,TPTEF/TE,IFN-γ and IL-10 in observation group were higher than those in control group(P＜0.05).The levels of CD3+,CD4+and CD4+/CD8+in both groups were significantly higher than before intervention,and the levels of CD8+were significantly lower than before intervention(P＜0.05).The levels of CD3+,CD4+and CD4+/CD8+in observation group were significantly higher than those in control group,and CD8+was significantly lower than that in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups(x2=0.704,P=0.401).Conclusion Both recombinant IFN-α-2b and ipratropium bromide atomized inhalation can achieve good therapeutic effect in children with bronchiolitis,but the former can help shorten the time of symptom disappearance and improve the immune level of children,and is worthy of clinical application.
