Curative effect of tiapride,vitamin B12 combined with transcranial magnetic stimulation on children with tic disorder
10.3969/j.issn.1673-9701.2024.25.002
- VernacularTitle:硫必利、维生素B12联合经颅磁刺激对儿童抽动障碍的疗效
- Author:
Duanxiu ZHANG
1
;
Laiying ZHANG
;
Zhihua YE
Author Information
1. 北京中医药大学东直门医院厦门医院/厦门市中医院儿科,福建厦门 361015
- Keywords:
Tic disorder;
Transcranial magnetic stimulation;
Vitamin B12;
Tiapride;
Serum S100β protein
- From:
China Modern Doctor
2024;62(25):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of tiapride,vitamin B12 combined with transcranial magnetic stimulation(TMS)in the treatment of children with tic disorder(TD)and the effect on serum S100β protein.Methods A total of 100 children with TD treated in Xiamen Hospital of Traditional Chinese Medicine from September 2021 to September 2023 were selected and divided into observation group and control group according to random number table method,with 50 cases in each group.The control group was treated with tiapride and vitamin B12,and the observation group was treated with tiapride and vitamin B12 combined with TMS.The clinical efficacy,serum S100β protein level,neurological function and adverse reactions of two groups were observed.Results The total effective rate of observation group was significantly higher than that of control group(x2=6.061,P=0.014).After treatment,serum S100β protein levels in both groups were significantly lower than before treatment,and sensory and motor scores were significantly higher than before treatment(P＜0.05).The serum S100β protein level in observation group was significantly lower than that in control group,and sensory and motor scores were significantly higher than those in control group(P＜0.05).There was no significant difference in incidence of adverse reactions between two groups(x2=0.177,P=0.674).Conclusion Tiapride and vitamin B12 combined with TMS have significant efficacy in treatment of TD children,which can reduce the level of serum S100β protein,effectively improve nerve function,and have good safety.
