Efficacy of contrast-enhanced ultrasound combined with serum AFP in predicting primary liver cancer by microwave ablation
10.3969/j.issn.1673-9701.2024.24.016
- VernacularTitle:超声造影联合血清AFP预测微波消融术治疗原发性肝癌的疗效
- Author:
Lu YIN
1
;
Dezhi YANG
;
Tingting LI
Author Information
1. 杭州市肿瘤医院超声影像科,浙江杭州 310000
- Keywords:
Contrast-enhanced ultrasound;
Alpha-fetoprotein;
Microwave ablation;
Primary liver cancer;
Prognosis
- From:
China Modern Doctor
2024;62(24):82-85,89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of contrast-enhanced ultrasound combined with serum alpha-fetoprotein(AFP)in the treatment of primary liver cancer by microwave ablation.Methods A total of 148 patients with primary liver cancer treated in Shulan(Hangzhou)Hospital from July 2020 to August 2022 were collected and divided into microwave ablation group and control group by random number table method,with 74 cases in each group.The microwave ablation group was treated with chemotherapy combined with microwave ablation,while the control group was treated with chemotherapy only,and the prognosis of two groups were compared.According to the prognosis,the microwave ablation group was divided into good prognosis group and poor prognosis group,.The differences in the cross-sectional area of microwave ablation foci and serum AFP index between the good prognosis group and the poor prognosis group were analyzed.The diagnostic value was analyzed by area under the curve(AUC),and the correlation was analyzed by Pearson method.Results The cumulative survival rates of the good prognosis group,the poor prognosis group,the microwave ablation group and the control group were 100.00％,10.71％,49.11％and 14.51％,respectively.Six months after operation,the cross-sectional area of microwave ablation foci in both the good prognosis group and the poor prognosis group increased,and the good prognosis group was larger than the poor prognosis group(P＜0.05);The serum AFP level in the good prognosis group was decreased,and the level in the poor prognosis group was increased(P＜0.05);The cross-sectional area of microwave ablation foci,serum AFP and AUC values of combined detection were 0.760,0.740 and 0.833,respectively.The cross-sectional area of microwave ablation and serum AFP were positively and negatively correlated with survival(P＜0.05).Conclusion Contrast-enhanced ultrasound combined with serum AFP has a good predictive value in the efficacy of primary liver cancer.
