Effect of marital status on the prognosis of prostate cancer patients based on SEER database
10.3969/j.issn.1673-9701.2024.24.014
- VernacularTitle:基于SEER数据库分析婚姻状况对前列腺癌患者预后的影响
- Author:
Ruimin HAN
1
;
Li SUN
;
Defeng WANG
;
Zhen WANG
Author Information
1. 河北工程大学临床医学院,河北邯郸 056038
- Keywords:
Prostate cancer;
Marital status;
Prognosis;
SEER database
- From:
China Modern Doctor
2024;62(24):71-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between marital status and prognosis of prostate cancer patients.Methods A total of 16 815 prostate cancer patients'data were extracted from the US SEER database,and the relationship between marital status and the prognosis of prostate cancer patients was assessed by using Log-rank unifactorial and multifactorial Cox risk-proportional models.Results ①At different stages of cancer,marital status can serve as an independent factor for tumor prognosis;②When the prostate-specific antigen(PSA)＜10ng/ml,the strongest correlation between marital status and prostate cancer survival rate was observed.There was a significant difference in tumor survival rate between different marital statuses with PSA＜10ng/ml and PSA levels between 10-20ng/ml;③ The survival curve and 5-year survival rate of patients with Gleason=7 points and Gleason ≥ 8 points in married group were significantly higher than those in unmarried group and divorced/widowed group;④ Patients who undergo surgical treatment have a longer survival time,and regardless of whether surgery is performed or not,the survival rate of married patients is significantly higher than that of patients with other marital statuses;⑤ In this study,the mortality risk of married prostate cancer patients was lower than that of patients with other marital statuses under different grouping conditions.Conclusion Marital status can be used as an independent prognostic factor for prostate cancer patients to a certain extent,and the mortality risk coefficient of married prostate cancer patients is lower than that of patients with other marital status.
