Expression and clinical significance of Ciz1 in colorectal cancer
10.3969/j.issn.1673-9701.2024.23.017
- VernacularTitle:周期素依赖性蛋白激酶抑制物1A相互作用锌指蛋白1在结直肠癌中的表达及其临床意义
- Author:
Jin CAO
1
;
Fangyuan GAO
;
Shengbo SUN
;
Huanhu ZHANG
;
Chuanji HAN
;
Qing GONG
;
Gangxing LI
Author Information
1. 山东大学附属威海市立医院胃肠外科,山东威海 2642021
- Keywords:
Ciz1;
Colorectal cancer;
Immunohistochemical
- From:
China Modern Doctor
2024;62(23):78-80,86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of ciz1 in human colorectal cancer tissues and analyse the relationship between their expression and clinicopathologic features.Methods We detected the expression of Ciz1 and Ciz1 mRNA by immunohistochemistry and Western blotting.The relationship between the expression of ciz1 and clinicopathologic features was analied.Results According to immunohistochemical results,Ciz1 showed significant high expression in the primary lesion of colorectal cancer tissue,compared to normal adjacent tissues(66.7%vs.35.0%,P=0.001).Through Western blot analysis,it was found that the relative expression level in colorectal cancer tissue was 0.32±0.03,while in normal colorectal mucosal tissue it was 0.11±0.01.In addition,the relative expression level of Ciz1 in colorectal cancer tissue was significantly higher than that in normal intestinal mucosal tissue(P<0.05).The study found that the overexpression of Ciz1 in colorectal cancer tissue is significantly correlated with the T stage(P=0.018),lymph node metastasis(P=0.022),and AJCC stage(P=0.017)of the cancer.The age,gender,tumor location,degree of differentiation,and the presence of distant metastasis of patients were not correlated with this(P>0.05).The expression level of Ciz1 in colorectal cancer tissue is significantly increased,which is closely related to the T stage(P=0.018),lymph node metastasis(P=0.022),and American Joint Committee on Cancer stage(P=0.017)of colorectal cancer.Conclusion This association suggests that Ciz1 may play an important role in tumor staging,participating in the development and spread of tumors.Therefore,it can be foreseen that Ciz1 is expected to become a new biomarker for evaluating the prognosis of colorectal cancer patients.
