Level of inflammatory factors and correlation with prognosis in chronic cervicitis patients with HPV infection
10.3969/j.issn.1673-9701.2024.23.012
- VernacularTitle:慢性宫颈炎合并HPV感染患者炎性因子水平与预后的相关性
- Author:
Chaojie HUA
1
;
Yun LYU
;
Qianqian HE
;
Qiongying CHEN
Author Information
1. 舟山市妇女儿童医院妇产科,浙江舟山 3160001
- Keywords:
Chronic cervicitis;
Human papilloma virus infection;
Inflammatory factor;
Clinicopathological features
- From:
China Modern Doctor
2024;62(23):53-56,77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the level of inflammatory factors and their correlation with prognosis in chronic cervicitis patients with human papillomavirus(HPV)infection.Methods Totally 100 patients from January 2022 to December 2023 were selected as the observation group.Among them,67 patients were 100 patients with low-risk HPV and 33 patients with high-risk HPV.At the same time,100 female personnel with physical examination in our hospital were selected as the control group.All of the patients were treated routinely.The C-reactive protein(CRP),interleukin(IL)-6,and serum amyloid A(SAA)levels were measured,and the patients were followed up for 6 months after treatment to observe the prognosis.Results Compared with the control group,The expression of CRP,IL-6 and SAA level increased in the observation group(P<0.05),Compared with the low-risk HPV group,The expression of CRP,IL-6 and SAA level increased in high-risk HPV group(P<0.05).Compared with patients with a good prognosis,Higher expression of CRP,IL-6 and SAA in patients with poor prognosis(P<0.05).The positive correlation between CRP,IL-6,SAA and low-risk HPV and high-risk HPV,Statistical difference(P<0.05).Negative correlation between CRP,IL-6,SAA and good prognosis,All showed a positive correlation between CRP,IL-6,and SAA and poor prognosis,There were statistical differences(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the diagnostic value of CRP,IL-6 and SAA(P<0.05).Conclusion Patients with chronic cervicitis have increased CRP,IL-6 and SAA in HPV infection,and the abnormal increased or decreased expression level is the risk predictor of chronic cervicitis with HPV infection,which may be closely related to the diagnosis of the disease,pathological characteristics,disease development and prognosis.
