Retrospective analysis of prognostic factors in patients with advanced gastric cancer
10.3969/j.issn.1673-9701.2024.22.016
- VernacularTitle:中晚期胃癌患者预后相关因素的回顾性分析
- Author:
Zhendong DUAN
1
;
Junhua HU
;
Zhongliang LIU
;
Jing ZHOU
Author Information
1. 舟山市中医院肿瘤科,浙江舟山 316000
- Keywords:
Advanced gastric cancer;
Survival analysis;
Risk factor;
COX regression
- From:
China Modern Doctor
2024;62(22):67-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors affecting the prognosis of patients with advanced gastric cancer,so as to provide evidence for identifying high-risk populations and guiding clinical treatment.Methods The clinical data of 282 patients with advanced gastric cancer who admitted to Zhoushan Hospital of Traditional Chinese Medicine from January 2017 to December 2021 were retrospectively analyzed.The survival outcome of patients was obtained by telephone follow-up and regular review.Kaplan-Meier method was used to analyze the overall survival(OS).Univariate and multivariate COX regression models were used to analyze the effects of clinical features on OS in patients with advanced gastric cancer.Results The median OS of 282 patients with advanced gastric cancer was 10.0 months.Univariate analysis showed that first-line chemotherapy,traditional Chinese medicine treatment,body mass index(BMI),Karnofsky performance status(KPS)score,hemoglobin(Hb)and albumin(Alb)were significantly correlated with the survival of patients with advanced gastric cancer(P<0.05).Multivariate COX regression models analysis showed that first-line chemotherapy,BMI,KPS score and Alb were independent risk factors affecting the survival of patients with advanced gastric cancer(P<0.05).Conclusion BMI,Alb,KPS score and first-line chemotherapy are independent risk factors for predicting the prognosis of patients with advanced gastric cancer,indicating nutrition management may be an important way to improve the outcome of patients with advanced gastric cancer.
