Relationship between AKIP1 and clinicopathological features and prognosis of cervical cancer
10.3969/j.issn.1673-9701.2024.21.014
- VernacularTitle:AKIP1与宫颈癌患者临床病理特征和预后的关系
- Author:
Jia TIAN
1
;
Dongrui QIN
;
Meng ZHANG
;
Yingchao LIU
Author Information
1. 聊城市第二人民医院病理科,山东临清 252600
- Keywords:
Cervical cancer;
A kinase interacting protein 1;
Clinicopathological features;
Prognosis;
Immunohistochemistry
- From:
China Modern Doctor
2024;62(21):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of A kinase interacting protein 1(AKIP1)in cervical cancer and analyze the correlation between AKIP1 and clinicopathological features and prognosis.Methods A total of 88 patients with cervical cancer admitted to the Second People's Hospital of Liaocheng from January 2016 to December 2018 were selected for the study.The expression of AKIP1 was detected by immunohistochemical staining,and its expression was judged to be negative or positive according to the score of staining results.The relationship between AKIP1 expression and clinicopathological features was analyzed by x2test;Kaplan-Meier curve was used to analyze the effect of AKIP1 on the prognosis of cervical cancer.Results Compared with the para-cancer tissues,the expression of AKIP1 was significantly increased in cervical cancer(P＜0.05);Patients with tumor diameter ≥4 cm,low differentiation,lymph node metastasis and FIGO stageⅡ-Ⅲ,the positive rate of AKIP1 was significantly higher than that of patients with tumor diameter＜4 cm,high differentiation,no lymph node metastasis and FIGO stage I,the difference is statistically significant(P＜0.05);Kaplan-Meier analysis showed that the survival rate of AKIP1 positive patients was significantly lower than that of AKIP1 negative patients(x2=5.162,P＜0.05).Conclusion The expression of AKIP1 is correlated with poor clinicopathologic features in patients with cervical cancer,and may be a biological marker affecting the prognosis of patients with cervical cancer.
