Relationship between the ratio of small dense low density lipoprotein and high-density lipoprotein and contrast nephropathy after emergency percutaneous coronary intervention in patients with acute STEMI and type 2 diabetes mellitus
10.3969/j.issn.1673-9701.2024.20.014
- VernacularTitle:sdLDL/HDL与急性STEMT合并2型糖尿病患者行急诊介入术后造影剂肾病发生的关系
- Author:
Di ZHENG
1
;
Kai MA
;
Wenhua LI
;
Yuhan LI
Author Information
1. 徐州医科大学附属医院心内科,江苏徐州 221000
- Keywords:
Small dense low density lipoprotein cholesterol;
High-density lipoprotein cholesterol;
Contrast nephropathy;
Acute ST segment elevation myocardial infarction;
Type 2 diabetes mellitus
- From:
China Modern Doctor
2024;62(20):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the ratio of small dense low density lipoprotein(HDL-C)and high-density lipoprotein(HDL-C)and contrast nephropathy(CIN)after emergency percutaneous coronary intervention(PCI)in patients with acute ST segment elevation myocardial infarction(STEMI)complicated with type 2 diabetes mellitus(T2DM).Method Totally 187 patients with STEMI complicated with T2DM from May 2021 to November 2023 were selected for emergency percutaneous coronary intervention.The creatinine level was measured within 48-72 hours after operation,which was divided into 52 cases in CIN group and 135 cases in non CIN group.The levels of sdLDL and HDL-c in all patients were measured,and the ratio between them was calculated.The difference of sdLDL/HDL-c between the two groups was compared,and its relationship with contrast nephropathy after emergency percutaneous coronary intervention was analyzed.Results SdLDL-C(1.283±0.432)mmol/L in CIN group was higher than that in non CIN group(0.884±0.436)mmol/L.HDL-C(0.822±0.213)mmol/L in CIN group was lower than that in non CIN group(1.013±0.224)mmol/L.sdLDL/HDL-C(1.712±0.793)in CIN group was higher than that in non CIN group(0.843±0.484).The difference was statistically significant(P＜0.05).Logistic regression analysis showed that among the risk factors of coronary heart disease,sdLDL-C/HDL-C was an independent risk factor for CIN after emergency intervention in STEMI patients with T2DM[OR=9.003,95％CI:3.510-23.089,P＜0.001].ROC curve showed that the area under the curve of sdLDL-C/HDL-C to predict the occurrence of CIN in STEMI patients with T2DM was 0.836,optimal truncation was 1.159,the sensitivity was 76.1％,and the specificity was 83.7％.Conclusion SdLDL-C/HDL-C is closely related to the occurrence of CIN after emergency percutaneous coronary intervention in patients with STEMI complicated with T2DM.It may be used as an indicator for predicting the risk of CIN and has clinical guiding significance.
