Effect of repetitive transcranial magnetic stimulation on inflammatory factors and cranial nerve factors in adolescent depression
10.3969/j.issn.1673-9701.2024.20.010
- VernacularTitle:重复经颅磁刺激对青少年抑郁症炎症和脑神经因子的影响
- Author:
Lingli ZHU
1
;
Mengxin WANG
Author Information
1. 衢州市第三医院心理科,浙江衢州 324000
- Keywords:
Repetitive transcranial magnetic stimulation;
Adolescent depression;
Inflammatory factors;
Cranial nerve factors
- From:
China Modern Doctor
2024;62(20):44-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of repetitive transcranial magnetic stimulation(rTMS)on the symptom treatment of adolescent depressed patients and the regulatory effect of serum inflammatory factors and cranial nerve factors.Methods A total of 110 adolescent patients with depression were analyzed from May 1,2022 to May 30,2023,including 55 in the observation group and 55 in the control group.emotional intelligence scale(EIS),the Hamilton depression scale(HAMD)and World Health Organization quality of life bref(WHOQOL BREF)were used to evaluate the emotional intelligence,depression and quality of life before treatment and 1.5 and 3.0 months after treatment.Serum 5-hydroxytryptamine(5-HT),glial fibrillary acidic protein(GFAP),brain-derived neurotrophic factor(BDNF),interleukin(IL)-1β,IL-6 and transforming growth factor(TGF)-β1 were detected,and the protein expression levels of IL-1β,IL-6 and TGF-β1 in peripheral blood cells were detected by Western blot.Results After 1.5 and 3.0 months of intervention,the EIS score and WHOQOL-BREF scores in were increased,and the observation group was higher than that of the control group(P＜0.01),and the HAMD score was lower than that of the control group(P＜0.01).After treatment,the levels of BDNF,5-HT and GFAP in the observation group were higher than those in the control group(P＜0.01).The levels of IL-1β and IL-6 were lower in the observation group,and the levels of TGF-β1 were higher(P＜0.01).Conclusion rTMS stimulation can further down-regulate the expression of pro-inflammatory factors(IL-1β,IL-6)and anti-inflammatory factors(TGF-β1)and cranial nerve factors(BDNF,GFAP,5-HT)in patients on the basis of basic drug treatment,so the use of rTMS stimulation in the treatment of adolescent depression has certain clinical application value.
