Constructing a predictive model for the severity of depression based on the expression of circRNAs in peripheral blood
10.3969/j.issn.1673-9701.2024.20.005
- VernacularTitle:基于外周血circRNAs构建抑郁症严重程度的预测模型
- Author:
Huanran YAN
1
;
Dongqin XU
;
Jing CHEN
Author Information
1. 绍兴市第七人民医院精神科,浙江绍兴 312000
- Keywords:
Circular RNA;
Depression;
Severity;
Prediction model
- From:
China Modern Doctor
2024;62(20):17-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct a predictive model for the severity of depression based on the expression of circular RNAs(circRNAs)in peripheral blood.Methods Selecting 80 patients with depression who visited our hospital from August 2022 to August 2023,they were divided into a mild to moderate group of 49 cases and a severe group of 31 cases.Forty healthy individuals were selected as the healthy group,and after gene chip screening,five circRNAs with significant differences were selected.Further analysis was conducted on the relationship between circRNAs and the severity of depression,and independent risk factors affecting the severity of depression were analyzed,based on the analysis results,construct a depression severity prediction model using a column chart based on the expression of circRNAs in peripheral blood.Results Compared with the healthy group and mild to moderate group,the severe group had circRNA_100679,circRNA_1 03636 relative expression level decreased,circRNA_102802,circRNA_103964,The relative expression level of circRNA_002143 increased(P＜0.05).CircRNA_100679,circRNA_103636 is negatively correlated with the severity of depression(r=-0.594,-0.512,P＜0.05),circRNA_102802,circRNA_103964,circRNA_002143 is positively correlated with the severity of depression(r=0.603,0.425,0.412,P＜0.05).CircRNA_100679,circRNA_102802,circRNA_103636,circRNA_103964,circRNA_002143,family history of mental illness,and 5-hydroxytryptamine(5-HT)are all risk factors for the severity of depression(P＜0.05).The predicted area under the curve of the column chart prediction model based on risk factors such as peripheral blood circRNAs is 0.900,with a 95％CI:0.811-0.945.The model has good discrimination and high internal validation consistency.Conclusion The construction of a column chart model based on circRNAs expression for predicting the severity of depression has good predictive value and can provide reference for the diagnosis and treatment of depression severity in clinical practice.
