Analysis of risk factors for antibiot-associated diarrhea in sepsis patients
10.3969/j.issn.1673-9701.2024.18.002
- VernacularTitle:脓毒症患者并发抗生素相关性腹泻的危险因素分析
- Author:
Weitao ZHENG
1
;
Shengchao WANG
;
Xing SHAO
;
Hongjie TONG
;
Kun CHEN
Author Information
1. 浙江大学医学院附属金华医院重症医学科,浙江金华 321000
- Keywords:
Sepsis;
Department of critical care medicine;
Antibiot-associated diarrhea;
Risk factors
- From:
China Modern Doctor
2024;62(18):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence and risk factors of antibiot-associated diarrhea(AAD)in patients with sepsis.Methods A total of 126 patients with sepsis admitted to Department of Critical Care Medicine,Jinhua Hospital Affiliated to Zhejiang University School of Medicine from July 2021 to July 2023 were selected as the subjects.They were divided into AAD group and non AAD group based on whether AAD occurred.Compare the clinical data and antibiotic use between two groups of patients,and use Logistic regression analysis to identify the risk factors for AAD in sepsis patients.Results There were 72 cases of respiratory system infections,18 cases of urinary system infections,15 cases of bloodstream infections,12 cases of chest and abdominal infections,and 9 cases of other infections in 126 patients with sepsis;32 cases(25.4%)developed AAD.Logistic multiple regression analysis showed that age≥60 years,lactic acid(Lac)level,albumin(ALB)level,use of carbapenems and enzyme inhibitors,combination of antibiotics,using hormones,and length of hospital stay were risk factors for AAD in sepsis patients(95%CI were 0.847-0.983,0.074-0.527,1.147-2.034,0.624-1.687,2.132-5.220,0.439-0.882,0.411-0.853,0.478-0.848,P<0.05).Conclusion Sepsis patients of department of critical care medicine have a high risk of developing AAD.Age≥60 years old,Lac level,ALB level,use of carbapenems and enzyme inhibitors,combination of antibiotics therapy,using hormones,and length of hospital stay are risk factors for AAD in sepsis patients.
