Prediction value of combined S/D ratio of umbilical artery and risk of eclampsia for predicting pregnancy outcomes in patients withgestational diabetes mellitus
10.3969/j.issn.1673-9701.2024.17.009
- VernacularTitle:子痫风险预测联合脐动脉S/D比值对妊娠期糖尿病患者妊娠结局的预测价值
- Author:
Haihong JIN
1
;
Xiuxiu WANG
Author Information
1. 浙江省台州医院妇产科,浙江台州 317000
- Keywords:
Gestational diabetes mellitus;
Placental growth factor;
Ratio of peak systolic velocity to end-diastolic velocity;
Decreased glucose tolerance;
Pregnancy outcome
- From:
China Modern Doctor
2024;62(17):38-41,46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of eclampsia risk prediction combined with umbilical artery peak systolic velocity/end diastolic velocity(S/D)ratio in predicting pregnancy outcomes in patients with gestational diabetes mellitus.Methods Select 60 cases of gestational diabetes mellitus(GDM)patients admitted to ourhospital's obstetrics outpatient department from January 2021 to January 2023 as the gestational diabetes group.At the same time,select 30healthy pregnant women who received regular prenatal check-ups in ourhospital's obstetrics outpatient department as the control group.Determination of placental growth factor(PIGF)in serum by magnetic particle chemiluminescence.The ratio of S/D ratio to was measured by ultrasound.At the same time,they were divided into good pregnancy outcome group and bad pregnancy outcome group according to whether combined with adverse pregnancy outcome,and the PIGF and S/D ratio were compared.We performed a predictive analysis using receiver operating characteristic(ROC)curve analysis to assess the predictive value of PIGF combined with the S/D ratio for the pregnancy outcomes in GDM patients.Results Compared with the control group,patients in the gestational diabetes mellitus(GDM)group showed a decrease in PIGF levels and an increase in the S/D ratio of systolic to diastolic velocities(S/D ratio)(P＜0.05).The incidence of adverse pregnancy outcomes was 46.67% in the GDM group,significantlyhigher than the 20.00% in the control group(P＜0.05).Compared with the group with favorable pregnancy outcomes,the GDM group with adverse pregnancy outcomeshad lower PIGF levels andhigher S/D ratio(P＜0.05).ROC curve analysis showed that both PIGF and S/D ratio were sensitive markers for predicting adverse pregnancy outcomes in GDM patients,with S/D ratio having ahigher diagnostic efficacy than PIGF alone,but the combination of both markers yielded greater accuracy.Conclusion The decrease of PIGF level and the increase of S/D ratio in patients with gestational diabetes mellitus are correlated with adverse pregnancy outcomes,and PIGF combined with S/D ratiohas thehighest diagnostic efficacy in patients with adverse pregnancy outcomes.
