Detection and recall analysis of treponema pallidum antibody in blood donors in Wenzhou area
10.3969/j.issn.1673-9701.2024.17.007
- VernacularTitle:温州地区献血者梅毒螺旋体抗体检测及召回分析
- Author:
Jie YANG
1
;
Feng ZHANG
;
Yaya WU
;
Xiaoyan CHEN
;
Yangyang LIN
Author Information
1. 温州市输血医学重点实验室温州市中心血站,浙江温州 325000
- Keywords:
Blood donor;
Syphilis;
Recall process;
False reaction
- From:
China Modern Doctor
2024;62(17):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective Through the detection of treponema pallida antibody in the unpaid blood donors in Wenzhou area,the recall self-test and recall test were carried out on the blood donors who were reactive to enzyme-linked immunosorbent assay(ELISA)test,and the feasibility of the recall plan was evaluated.Methods From January 2021 to May 2023,275 652 blood donors who successfully participated in unpaid blood donation were tested by anti-treponema pallidum(TP)ELISA,the reactivity rate and S/CO value of different reagents were compared,and the reactivity of single reagent was detected by ELISA.In addition,24 blood donors who volunteered to participate in the recall more than six months after the last blood donation screening were informed of the recall by way of interview,targeted health consultation,general examination and preliminary screening test were passed,and blood samples were collected for recall self-test and recall test.Results A total of 275 652 people were tested by anti-TP ELISA,and 627 cases were found to be reactive,with a reactivity rate of 0.23% ,including a double reagent reactivity rate of 0.12% and a single reagent reactivity rate of 0.11% .The ratio of S/CO≥5.00 with double reagent was 73.6% (240/326),and the ratio of S/CC＜5.00 with single reagent was 92.4% (278/301).24 people entered the recall process,20 people were successfully recalled,3 people failed to pass the self-test and 1 person failed to pass the test.The recall success rate was 83.3% (20/24).Conclusion The problem of false reactivity of anti-TP ELISA test single reagent in blood collection and supply institutions is prominent.Through the established recall scheme,the self-test and recall test of blood donors with strong recall intention can not only ensure the safety of blood donors,but also improve the construction of blood collection and supply service system.
