Diagnostic value of quantitative energy spectrum CT and multi-parameter magnetic resonance imaging on EGFR mutation in lung adenocarcinoma
10.3969/j.issn.1673-9701.2024.15.016
- VernacularTitle:能谱CT定量和多参数磁共振成像对肺腺癌EGFR突变相关性的诊断价值
- Author:
Biao ZHU
1
;
Hongyan AO
;
Qi HONG
;
Shenlin JIANG
Author Information
1. 景德镇市中医医院CT室,江西景德镇 333000
- Keywords:
Energy spectrum CT quantitative;
Multi-parameter magnetic resonance imaging;
Lung adenocarcinoma;
Epidermal growth factor receptor
- From:
China Modern Doctor
2024;62(15):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of quantitative energy spectrum CT and multi-parameter magnetic resonance imaging(MRI)on epidermal growth factor receptor(EGFR)mutation in lung adenocarcinoma.Methods Clinical data of 93 patients diagnosed with lung adenocarcinoma and EGFR mutation status by pathology in Jingdezhen Hospital of Traditional Chinese Medicine from June 2020 to June 2022 were retrospectively analyzed.They were divided into mutation group(52 cases)and wild-type group(41 cases)according to EGFR mutation status,and all patients were given quantitative spectral CT and MRI examinations.Changes in parameters between two groups were compared.Results CT40kev,CT70kev,spectral curve slope(λHU),effective atomic number and iodine concentration in arterial and venous phases in mutation group were significantly higher than those in wild-type group(P<0.05).Apparent diffusion coefficient(ADC)and true diffusion coefficient(D)of mutant group were significantly higher than those of wild-type group,while volume transport constant(Ktrans)and reflux rate constant(Kep)of mutant group were significantly lower than those of wild-type group(P<0.05).Analysis of receiver operating characteristics curve showed that area under the curve(AUC)value for CT40kev,CT70kev,λHU,effective atomic number,iodine concentration,CT comprehensive parameters,ADC,D,Ktrans,Kep and MRI comprehensive parameters for diagnosing EGFR mutation status in lung adenocarcinoma were 0.615,0.622,0.680,0.715,0.655,0.855,0.899,0.795,0.740,0.751 and 0.968 respectively.There was statistically significant difference in AUC between CT comprehensive parameters and MRI comprehensive parameters(P<0.05).Conclusion Both quantitative energy spectrum CT and multi-parameter MRI have high diagnostic value in the diagnosis of EGFR mutation status of lung adenocarcinoma,but MRI has higher diagnostic value,which is helpful to provide objective basis for accurate assessment of EGFR mutation status.
