Polysomnography and serum 5-HT study on Parkinson's disease sleep disorder
10.3969/j.issn.1673-9701.2024.15.014
- VernacularTitle:帕金森病睡眠障碍多导睡眠监测及血清5-HT研究1
- Author:
Yuelu WU
1
;
Zhuyan AN
;
Biwen WU
;
Jiaye CAI
;
Yamei YU
;
Xinggang FENG
Author Information
1. 中国人民解放军联勤保障部队第九〇三医院神经内科,浙江杭州 310004
- Keywords:
Parkinson's disease;
Sleep disorders;
Polysomnography parameters;
5-hydroxytryptamine
- From:
China Modern Doctor
2024;62(15):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between sleep disorders and polysomnography parameters and serum 5-hydroxytryptamine(5-HT)levels in Parkinson's disease patients.Methods 80 Parkinson's disease patients admitted of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from July 2021 to June 2023 were collected,and based on the Pittsburgh sleep quality index(PSQI)score divided them into study group(n=46,PSQI>10 points)and control group(n=34,PSQI≤10 points).Overnight polysomnography monitoring on two groups of patients was conducted,serum 5-HT levels were detected,polysomnography parameters and serum 5-HT levels between two groups were compared,and the correlation between sleep disorders and polysomnography parameters and serum 5-HT levels were analyzed.Results The total sleep time of study group was significantly shorter than that of control greup,sleep efficiency,and minimum blood oxygen saturation of study group were significantly lower than those of control group(P<0.05).The serum 5-HT levels in study group were significantly lower than those in control group(P<0.05).Correlation analysis showed that the PSQI score was negatively correlated with total sleep time,sleep efficiency,minimum blood oxygen saturation,and serum 5-HT levels(P<0.05).Conclusion Sleep disorders in Parkinson's disease patients are associated with decreased total sleep time,sleep efficiency,minimum blood oxygen saturation and serum 5-HT levels.
