Effect of dapagliflozin on cardiac function and inflammatory factors of patients with type 2 diabetic mellitus with paroxysmal atrial fibrillation
10.3969/j.issn.1673-9701.2024.13.016
- VernacularTitle:达格列净对2型糖尿病合并阵发性房颤患者心功能及炎症因子的影响分析
- Author:
Chenchen QIAO
1
;
Kemin LI
Author Information
1. 蚌埠市第一人民医院心血管内科,安徽蚌埠 233000
- Keywords:
Dapagliflozin;
Paroxysmal atrial fibrillation;
Inflammatory factor
- From:
China Modern Doctor
2024;62(13):60-63,72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dapagliflozin on cardiac function and inflammatory factors of patients with type 2 diabetic mellitus(T2DM)with paroxysmal atrial fibrillation(PAF).Methods A total of 100 T2DM patients with PAF treated in Bengbu First People's Hospital from January 2021 to June 2022 were selected and divided into control group and observation group according to the treatment plan,with 50 cases in each group.Patients in both groups were given conventional treatment,and patients in observation group were given dapagliflozin on the basis of conventional treatment.Both groups were treated for 6 months.The cardiac function indexes and serum inflammatory factors were compared between two groups before and after treatment.Results After 6 months of treatment,left ventricular end diastolic diameter(LVEDD)and left atrium diameter(LAD)in both groups were significantly lower than before treatment,left ventricular ejection fraction(LVEF)was significantly higher than that before treatment,and serum hypersensitive C-reaction protein(hsCRP),interleukin-6(IL-6)and monocyte to high density lipoprotein-cholesterol ratio(MHR)were significantly lower than before treatment(P<0.05).LVEDD and LAD in observation group were significantly lower than those in control group,LVEF was significantly higher than those in control group,serum hsCRP,IL-6 and MHR were significantly lower than those in control group(P<0.05).Conclusion Dapagliflozin can significantly improve the cardiac function and reduce the level of inflammatory factors in T2DM patients with PAF,which has good clinical application value.
