Progress of the relationship between sialylation and tumors

VernacularTitle:唾液酸化与肿瘤关系的研究进展
Author: Liangbin GAO ¹ ; Wei AN ; Wenge CHEN
Author Information

1. 山西医科大学口腔医学院，太原　030001
Keywords: Sialic acids; Neoplasms; Treatment
From: Cancer Research and Clinic 2024;36(11):876-880
CountryChina
Language:Chinese
Abstract: Sialic acid is a member of the nine-carbonic acidic monosaccharide family, which is abnormally expressed in various malignant tumors and significantly associated with prognosis of patients. The addition of sialic acid to glycoproteins and glycolipids causes sialylation, which is a post-translational modification usually found at the end of glycan chains and regulates various physiological and pathological processes. Abnormal sialylation would affect many critical processes in tumors, including immune evasion, resistance to apoptosis, metastasis and proliferation. Therefore, exploring the mechanisms of sialylation in tumors is beneficial for finding new cancer treatment methods. This article reviews the relationship between sialylation and tumors.