Analysis of the reasons for diffuse uptake of 131I in both lungs of differentiated thyroid cancer patients after 131I treatment
10.3760/cma.j.cn115355-20240105-00013
- VernacularTitle:分化型甲状腺癌患者 131I治疗后双肺弥漫性摄取 131I原因分析
- Author:
Yanxia MI
1
;
Lili WANG
;
Ming ZHAO
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院核医学科，太原 030013
- Keywords:
Thyroid neoplasms;
Iodine;
Neoplasm metastasis;
Lung;
Tomography
- From:
Cancer Research and Clinic
2024;36(9):683-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the possible reasons for diffuse uptake of 131I in both lungs of differentiated thyroid cancer (DTC) patients after 131I treatment. Methods:A retrospective case series study was conducted. Forty-six DTC patients who received 131I treatment at Shanxi Province Cancer Hospital from June 2015 to June 2021 were collected, and whole body scan of these patients showed diffuse uptake of 131I in both lungs on the 7th day after treatment. Based on SPECT/CT fusion images, thyroid globulin levels, and thyroid globulin antibody (TgAb) levels, the possible reasons for diffuse uptake of 131I in both lungs were analyzed. Results:SPECT/CT fusion images showed no abnormal density shadows in 10 patients; stimulating thyroglobulin (sTg) was (11±4) ng/ml, TgAb was (1.2±0.5)%, inhibitory thyroglobulin was (5.3±1.5) ng/ml; the possible reason for diffuse uptake of 131I in both lungs was the presence of early small metastatic nodules that cannot be detected by conventional CT scans, and these nodules absorbed 131I. SPECT/CT fusion images showed multiple round nodules in both lungs in 36 patients; sTg was (281±10) ng/ml, TgAb was (1.7±0.7) %; the reason for diffuse uptake of 131I in both lungs was the uptake of 131I by metastatic lesions in both lungs. Conclusions:Different degrees of tumor metastasis may be the cause of diffuse uptake of 131I in both lungs of DTC patients after 131I treatment.
