Progress of morphine in neoplasms
10.3760/cma.j.cn115355-20231025-00162
- VernacularTitle:吗啡在肿瘤中的研究进展
- Author:
Licui LIU
1
;
Yongbin ZHENG
Author Information
1. 武汉大学人民医院胃肠Ⅰ科，武汉 430061
- Keywords:
Neoplasms;
Morphine;
Pain;
Adverse reactions
- From:
Cancer Research and Clinic
2024;36(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Pain is one of the most common symptoms of tumors for cancer patients, especially those with advanced tumors. As a classic opioid that can relieve pain, morphine is widely applied in cancer patients. However, morphine has certain limitations in clinical application, for example, the long-term usage of morphine can result in analgesic tolerance and hyperalgesia, cause resistance to other chemotherapy drugs, and weaken the efficacy of chemotherapy drugs. When morphine is combined with some drugs, the adverse effects of morphine can be reduced. And the effect of morphine on tumor immunity, growth, metastasis, angiogenesis and apoptosis is also complex, and different concentrations and experimental models will have an impact on the efficacy of morphine, and the specific mechanism of these effects needs to be further explored. This paper reviews the characteristics, clinical use and the influence of morphine on cancer development.
