Progress of mTOR signaling pathway in tumors
10.3760/cma.j.cn115355-20231227-00206
- VernacularTitle:mTOR信号通路在肿瘤中的研究进展
- Author:
Fuxin HAN
1
;
Yuting LU
;
Weidong HAN
;
Yao WANG
Author Information
1. 解放军总医院第一医学中心生物治疗科，北京 100853
- Keywords:
Neoplasms;
TOR serine-threonine kinases;
Signal transduction;
Cell transformation, neoplastic
- From:
Cancer Research and Clinic
2024;36(6):473-477
- CountryChina
- Language:Chinese
-
Abstract:
The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in tumorigenesis, development of tumor and tumor therapy. Previous studies have reported on the abnormalities of mTOR signaling pathway leading to the development of a variety of malignant tumors and the antitumor efficacy of various mTOR inhibitors. However, multiple studies in recent years on the mechanisms of drug resistance in tumor therapy with chemotherapy or programmed death receptor 1 inhibitors have focused on the possibility that inhibition of mTOR signaling may be associated with tumor resistance to therapy. This article summarizes the physiological functions of mTOR signaling pathway and its regulatory mechanisms in tumorigenesis, and provides a review for its mechanism of action in tumor therapy sensitivity.
