Efficacy comparison between sufentanil combined with butorphanol and sufentanil combined with dezocine for postoperative analgesia of single-port thoracoscopic lobectomy
10.3760/cma.j.cn115355-20230820-00059
- VernacularTitle:舒芬太尼联合布托啡诺与舒芬太尼联合地佐辛用于单孔胸腔镜肺叶切除术后镇痛的效果比较
- Author:
Jing NIU
1
;
Jinxiu KANG
;
Na LIU
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院麻醉科，太原 030013
- Keywords:
Thoracoscopes;
Surgical procedures, operative;
Analgesia;
Butorphanol;
Dezocine;
Sufentanil
- From:
Cancer Research and Clinic
2024;36(6):454-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of sufentanil combined with butorphanol and sufentanil combined with dezocine for postoperative analgesia of single-port thoracoscopic lobectomy.Methods:A prospective randomized controlled study was conducted. A total of 72 patients who underwent single-port thoracoscopic lobectomy in Shanxi Province Cancer Hospital from October to December 2023 were prospectively selected, and the patients were divided into group A and group B according to randomized numerical table method, with 36 cases in each group. Group A used sufentanil combined with dezocine for postoperative analgesia; group B used sufentanil combined with butorphanol for postoperative analgesia. The visual analogue scale (VAS) scores of pain, Ramasy sedation scores, vital signs monitoring indexes, postoperative adverse reactions, and the time of removing the closed chest drain were compared between the two groups at different time points in the postoperative period.Results:There were 20 males (55.6%) and 16 females (44.4%) in group A, aged (58±10) years old; there were 16 males (44.4%) and 20 females (55.6%) in group B, aged (56±11) years old; there were no statistically significant differences between the two groups in terms of gender, age, body mass index, American Society of Anesthesiologists classification, and surgery time (all P > 0.05). Comparison of the VAS scores of the two groups at 2, 6 and 10 h after surgery showed no statistically significant differences (all P > 0.05); the VAS scores of group B at 12, 24 and 48 h were lower than those of group A, and the differences were statistically significant (all P < 0.01). The Ramasy scores of the patients in group B at 2, 6, 10, 12, 24, and 48 h after surgery were higher than those of group A, and the differences were statistically significant (all P < 0.05). The postoperative chest drain removal time in group A was (4.5±1.7) d, which was longer than that in group B [(3.7±0.8) d], and the difference was statistically significant ( t= 2.58, P = 0.014). Comparison of systolic blood pressure, diastolic blood pressure, oxygen saturation, heart rate, and respiration of patients in the two groups at 2, 6, 10, 12, 24, and 48 h after surgery showed no statistically significant differences (all P > 0.05). The incidence of postoperative adverse reactions in patients of both groups was 16.67% (6/36). Conclusions:The efficacy of sufentanil combined with butorphanol for postoperative analgesia of single-port thoracoscopic lobectomy is better than that of sufentanil combined with dezocine, which may help to accelerate the patient's postoperative recovery.Objective To investigate the efficacy of sufentanil combined with butorphanol and sufentanil combined with dezocine for postoperative analgesia of single-port thoracoscopic lobectomy. Methods A prospective randomized controlled study was conducted. A total of 72 patients who underwent single-port thoracoscopic lobectomy in Shanxi Province Cancer Hospital from October to December 2023 were prospectively selected, and the patients were divided into group A and group B according to randomized numerical table method, with 36 cases in each group. Group A used sufentanil combined with dezocine for postoperative analgesia; group B used sufentanil combined with butorphanol for postoperative analgesia. The visual analogue scale (VAS) scores of pain, Ramasy sedation scores, vital signs monitoring indexes, postoperative adverse reactions, and the time of removing the closed chest drain were compared between the two groups at different time points in the postoperative period. Results There were 20 males (55.6%) and 16 females (44.4%) in group A, aged (58±10) years old; there were 16 males (44.4%) and 20 females (55.6%) in group B, aged (56±11) years old; there were no statistically significant differences between the two groups in terms of gender, age, body mass index, American Society of Anesthesiologists classification, and surgery time (all P > 0.05). Comparison of the VAS scores of the two groups at 2, 6 and 10 h after surgery showed no statistically significant differences (all P > 0.05); the VAS scores of group B at 12, 24 and 48 h were lower than those of group A, and the differences were statistically significant (all P < 0.01). The Ramasy scores of the patients in group B at 2, 6, 10, 12, 24, and 48 h after surgery were higher than those of group A, and the differences were statistically significant (all P < 0.05). The postoperative chest drain removal time in group A was (4.5±1.7) d, which was longer than that in group B [(3.7±0.8) d], and the difference was statistically significant ( t= 2.58, P = 0.014). Comparison of systolic blood pressure, diastolic blood pressure, oxygen saturation, heart rate, and respiration of patients in the two groups at 2, 6, 10, 12, 24, and 48 h after surgery showed no statistically significant differences (all P > 0.05). The incidence of postoperative adverse reactions in patients of both groups was 16.67% (6/36). Conclusions The efficacy of sufentanil combined with butorphanol for postoperative analgesia of single-port thoracoscopic lobectomy is better than that of sufentanil combined with dezocine, which may help to accelerate the patient's postoperative recovery.
