Efficacy and safety of endoscopic argon ion coagulation combined with mesalazine enteric fluid in the treatment of chronic radiation proctitis
10.3760/cma.j.cn115355-20230410-00175
- VernacularTitle:内镜下氩离子凝固术联合美沙拉嗪灌肠液治疗慢性放射性直肠炎的效果及安全性
- Author:
Libin ZHANG
1
;
Wenbin ZHANG
;
Bin GUO
;
Erfeng LI
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院内镜中心，太原 030013
- Keywords:
Proctitis;
Radiation injuries;
Argon plasma coagulation;
Mesalazine;
Enema;
Hemorrhage
- From:
Cancer Research and Clinic
2024;36(5):381-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of endoscopic argon ion coagulation combined with mesalazine enteric fluid in the treatment of chronic radiation proctitis with hemorrhage.Methods:A retrospective case control study was conducted. The clinical data of 82 patients with chronic radiation proctitis with hemorrhage admitted to Shanxi Province Cancer Hospital from January 2019 to January 2022 were retrospectively analyzed. According to the treatment methods, all patients were divided into the observation group (endoscopic argon ion coagulation combined with mesalazine enteric fluid retention enema, 44 cases) and the control group (0.9% NaCl solution 20 ml + thrombin 1 000 U combined with mesalazine enteric fluid retention enema, 38 cases). The clinical efficacy, proctoscopy scores, laboratory indexes [C-reactive protein (CRP), hemoglobin (Hb)] and the adverse reactions of the two groups 1 month after treatment were compared.Results:There were no statistically significant differences in gender, age, body mass index and disease classification between the two groups (all P > 0.05). After 1 month of treatment, the total effective rate of the observation group was higher than that of the control group [93.18% (41/44) vs.76.32% (29/38)], and the difference was statistically significant ( χ2 = 4.64, P = 0.031). The degree of intestinal injury, anal pain and naked blood stool in the observation group were lower than those in the control group (all P < 0.05). The level of CRP 1 month after treatment was lower than that before treatment in both groups, and the level of Hb 1 month after treatment was higher than that before treatment in both groups (all P < 0.001); and there were no statistically significant differences in the levels of CRP ahd Hb before treatment and 1 month after treatment between the both groups (all P > 0.05). There was no statistically significant difference in the adverse reactions between the two groups ( P > 0.05). Conclusions:Endoscopic argon ion coagulation combined with mesalazine enteric fluid in the treatment of chronic radiation proctitis with hemorrhage has a favorable effect and a good safety, which can improve the symptoms of hematochezia, diarrhea, anemia and improve the quality of life of patients.
