Progress in intrathecal therapy for solid tumor meningeal metastasis
10.3781/j.issn.1000-7431.2024.2304-0206
- VernacularTitle:实体瘤脑膜转移鞘内药物治疗进展
- Author:
Qiong ZHAN
1
;
Xiaohua LIANG
Author Information
1. 复旦大学附属华山医院肿瘤科,上海 200400
- Keywords:
Meningeal metastasis;
Intrathecal chemotherapy
- From:
Tumor
2024;44(1):70-76
- CountryChina
- Language:Chinese
-
Abstract:
Solid tumor meningeal metastasis is a catastrophic complication in the late stage of tumors,with a poor prognosis and currently lacking effective treatment methods.As a treatment method for meningeal metastasis,intrathecal chemotherapy has been recommended by many guidelines or expert consensus,and is often used in clinical practice.However,the efficacy of intrathecal chemotherapy has always lacked high-quality research evidence to support it.The efficacy of commonly used intrathecal chemotherapy drugs such as methotrexate,cytarabine,and thiotepa is not ideal.This article summarizes the usage,efficacy,and safety of new intrathecal injection drugs.
