Effects of Traditional Chinese Medicine Acupuncture Combined with Low-Dose Atropine on Macular Microcirculation in Chil-dren with Low Myopia
10.16466/j.issn1005-5509.2024.10.005
- VernacularTitle:中医针刺联合低浓度阿托品对低度近视儿童黄斑微循环的影响
- Author:
Wei GE
1
;
Qiushi LI
;
Liwei ZHU
Author Information
1. 浙江省中西医结合医院眼科 杭州 310003
- Keywords:
low myopia;
children;
macular vascular density;
retinal thickness;
traditional Chinese medicine acupuncture;
low-dose atropine;
ganglion cells-inner plexiform layer;
optical coherence tomography angiography
- From:
Journal of Zhejiang Chinese Medical University
2024;48(10):1233-1239
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effects of traditional Chinese medicine acupuncture combined with 0.01%atropine eye drops on macular vascular density and retinal thickness in children with low myopia.[Methods]A total of 84 children(156 eyes)newly diagnosed as low myopia were randomly divided into an experimental group and a control group.The experimental group received traditional Chinese medicine acupuncture combined with 0.01%atropine eye drops,while the control group was treated with 0.01%atropine eye drops alone.Ophthalmic examinations were performed before and after six months of treatment,including uncorrected distance visual acuity(UCVA),axial length(AL),spherical equivalent(SE),and slit-lamp examination.Optical coherence tomography(OCT)was used in routine mode to measure macular ganglion cell-inner plexiform layer(mGCIPL)thickness,and optical coherence tomography angiography(OCTA)was employed to measure macular vascular density and the area of the foveal avascular zone(FAZ).Changes in various indicators before and after treatment were compared between the two groups.[Results]After six months of treatment,both groups showed significant increases in AL and SE compared with that before treatment(P<0.01).The differences in AL and SE were significantly smaller in the experimental group than in the control group(P<0.05).No significant changes in intraocular pressure(IOP)were observed in either group before and after treatment(P>0.05).Compared to before treatment,both groups exhibited significant increases in mGCIPL thickness(P<0.01,P<0.05).Central circle macular vessel density(cCVD)increased in the experimental group(P<0.01),while there was no significant changes in outer circle macular vessel density(oCVD),inner circle macular vessel density(iCVD),whole circle macular vessel density(wCVD)or FAZ(P>0.05).After six months of treatment,no correlation was found between cCVD and AL or SE in the experimental group(P>0.05),but cCVD was positively correlated with mGCIPL thickness(r=0.448,P<0.05).[Conclusion]Traditional Chinese medicine acupuncture combined with 0.01%atropine eye drops can further reduce the growth rate of AL and diopter in children with low myopia.Additionally,this combined treatment increases cCVD and mGCIPL thickness in these children.
