Research Progress on the Role of Inflammatory Factors in the Pathogenesis of Damp-Heat Type-2 Diabetes and Traditional Chinese Medicine Treatment
10.16466/j.issn1005-5509.2024.07.020
- VernacularTitle:2型糖尿病发病中炎症因子的作用和中医从湿热论治的研究进展
- Author:
Yuqin LOU
1
;
Xuhong JIANG
Author Information
1. 浙江中医药大学 杭州 310053
- Keywords:
type 2 diabetes mellitus;
inflammatory factor;
insulin resistance;
pancreas β cell dysfunction;
damp heat syndrome;
traditional Chinese medicine
- From:
Journal of Zhejiang Chinese Medical University
2024;48(7):881-885,894
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To summarize the research and understanding on the role of inflammatory factors in the onset of type-2 diabetes(T2DM)at home and abroad,the correlation between damp-heat syndrome and inflammation in T2DM,and the experience of traditional Chinese medicine(TCM)in treating T2DM from damp-heat syndrome,so as to provide new ideas for the treatment of T2DM.[Methods]Reviewing relevant information on T2DM,reading relevant literature,summarizing the research results on the role of inflammatory factors in the pathogenesis of T2DM at home and abroad,summarizing the correlation between damp-heat syndrome and inflammation in TCM,and summarizing the experience of treating T2DM from the perspective of damp-heat in TCM.[Results]The onset of T2DM is closely related to inflammatory factors,inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)in the serum of T2DM patients are higher than normal levels.The role of inflammatory factors in the pathogenesis of T2DM includes hindering normal tyrosine phosphorylation in the insulin receptor substrate(IRS),accelerating the dissociation and degradation of IRS and phosphatidylinositol 3-kinases(PI3K),affecting downstream PI3K phosphorylation,interfering with insulin signaling through the pathway,and triggering insulin resistance(IR);promoting nuclear factor-κB(NF-κB)activation continuously exacerbates the inflammatory state through a positive feedback mechanism,promoting IR;directly or indirectly causing pancreatic islets β cellular destruction and decreasing insulin secretion function.TCM syndrome differentiation of T2DM patients is mostly characterized by damp-heat syndrome,the levels of IL-6 and hypersensitive-C reactive protein(hs-CRP)in T2DM damp heat syndrome are higher.Lipid metabolism disorders,IR and inflammation are more severe.There is a strong correlation between T2DM damp-heat syndrome and the inflammatory state of the body.TCM can reduce the level of inflammatory factors in the body by using various TCM formulas and single drugs to treat T2DM damp-heat syndrome.[Conclusion]There is a correlation among T2DM,inflammation and damp-heat syndrome.T2DM mostly belongs to damp-heat syndrome.The use of TCM formulas for clearing heat and removing dampness and single drugs is effective in treating T2DM damp-heat syndrome,which is a new approach to treat T2DM from the perspective of damp-heat theory.
