Discussion on the Mechanism of Treating Ulcerative Colitis with Huangya Decoction Based on"Spleen Being in Charge of the Defensive Function"
10.16466/j.issn1005-5509.2024.07.017
- VernacularTitle:基于"脾主为卫"的黄芽汤治疗溃疡性结肠炎机制探讨
- Author:
Si WANG
1
,
2
;
Jiabao LIAO
;
Lei LI
Author Information
1. 云南中医药大学云南省中西医结合慢病防治重点实验室 昆明 650500
2. 云南中医药大学第一临床医学院
- Keywords:
spleen being in charge of the defensive function;
strengthening the spleen and enriching Qi;
Huangya Decoction;
ulcerative colitis;
immunological function;
underlying mechanism
- From:
Journal of Zhejiang Chinese Medical University
2024;48(7):855-861
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To enrich the modern scientific connotation of the theory"spleen being in charge of the defensive function"in traditional Chinese medicine,and provide ideas for experimental research and clinical treatment of ulcerative colitis(UC).[Methods]Starting from the congruency between the therapeutic principle and method for UC in traditional Chinese medicine and the theory"spleen being in charge of the defensive function",and taking into account the fact that various components of Huangya Decoction were scientifically proven to effectively alleviate UC symptoms,this article discussed the potential mechanism of classic formula of Huangya Decoction in treating UC via"strengthening the spleen and enriching Qi"by explaining the theoretical connotation and immunological extension of"spleen being in charge of the defensive function",and combining with modern pharmacological research.[Results]Although studies on the treatment of UC by Huangya Decoction are still lacking,Huangya Decoction is feasible to treat UC by strengthening the spleen and enriching Qi based on the theory"spleen being in charge of the defensive function"in traditional Chinese medicine.The potential mechanisms include regulating immune cells,protecting intestinal epithelial barrier function,regulating intestinal flora,inhibiting or alleviating inflammatory response and regulating autophagy pathway expression.[Conclusion]The theoretical connotation of"spleen being in charge of the defensive function"in traditional Chinese medicine exhibits homologous physiological effects with the immune function in modern medicine,resulting from the synergistic action of multiple organs such as the spleen and gastrointestinal tract.The application of Huangya Decoction,a classic formula of strengthening the spleen and enriching Qi,for the treatment of UC through multi-target and multi-link approaches is not only feasible but also provides new insights for UC therapy.It lays a foundation for the systematic research,development and utilization of basic theories in traditional Chinese medicine and classic formulas.
