Comparison of skin physiological barrier function and its correlation with severity of acne in patients of different genders
10.3760/cma.j.issn.1671-0290.2024.06.006
- VernacularTitle:不同性别痤疮患者皮肤生理屏障功能的比较以及与痤疮严重程度的相关性分析
- Author:
Qi WANG
1
;
Ying FAN
;
Shiqin TAO
Author Information
1. 江南大学附属中心医院无锡市第二人民医院皮肤科，无锡 214000
- Keywords:
Acne vulgaris;
Transepidermal water loss;
Skin hydration;
Age;
Erythema index;
Melanin index
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2024;30(6):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the skin biophysical properties in acne patients of different gender and to further explore their association with skin biophysical properties.Methods:A total of 236 patients with acne vulgaris from the Department of Dermatology, Wuxi Second People＇s Hospital from April 2021 to December 2022 were prospectively enrolled, including 84 males and 152 females, with a median age of 26 (12-45) years. In addition, 62 healthy controls without skin diseases were included in this hospital during the same period, including 30 males and 32 females, with a median age of 27 (13-45) years. CK skin detector and VISIA skin image analyzer were used to detect physiological barrier parameters of the skin in the healthy control group and acne patient group, including transepidermal water loss (TEWL), skin hydration, pH value, erythema index, and melanin index. Global Acne Grading System (GAGS) score was used to assess the severity of acne. The aim was to compare the differences in the above skin physiological barrier parameters between male and female acne patients, and to explore their correlation with the severity of acne.Results:Compared with the female acne group, the male acne group had higher GAGS score, higher TEWL value, lower skin hydration, higher erythema index and melanin index, and the differences were statistically significant (all P<0.05). There was a weak positive correlation between the TEWL value and the number of comedones ( r=0.14, P=0.045) as well as the GAGS score ( r=0.15, P=0.036) in female acne patients; The TEWL value was weakly negatively correlated with skin hydration ( r=-0.24, P=0.002). The age of male acne patients was moderately positively correlated with pH value ( r=0.45, P=0.003). The erythema index was weakly positively correlated with the number of nodular cysts ( r=0.34, P=0.002) and the melanin index ( r=0.35, P=0.018); The TEWL value was moderately negatively correlated with skin hydration ( r=-0.44, P=0.003). Conclusions:Compared with female acne patients, male patients have poorer skin physiological barrier function. The worse the physiological barrier function of female patients＇ skin, the more severe their acne. There is no correlation between the skin physiological barrier function and the severity of acne in male patients.
