Research progress of novel DNAzyme biosensing technology in liquid biopsy for tumors

VernacularTitle:新型DNA酶生物传感技术在肿瘤液体活检中的研究进展
Author: Jiangnan ZENG ¹ ; Pan YANG ; Liyi LI ; Weiling FU ; Yongzhong WU ; Yang ZHANG
Author Information

1. 重庆大学医学院临床医学2022级、2023级，重庆　400044
Keywords: Biosensing techniques; Liquid biopsy; DNAzyme; Molecular diagnostic techniques
From: Chinese Journal of Laboratory Medicine 2024;47(11):1355-1360
CountryChina
Language:Chinese
Abstract: Tumors pose a serious challenge to global public health. The sensitive and precise detection of tumor biomarkers is very important for early screening and diagnosis of cancers. DNAzymes with outstanding physical, chemical, and biological properties are widely applied in the design of biosensing strategies. By the use of sensing platforms such as fluorescence, electrochemistry, and surface-enhanced Raman scattering, DNAzymes facilitate the early screening and detection of tumors. This article summarizes the functional mechanism and common classifications of DNAzymes, and the updates of DNAzymes-based novel biosensing technologies within the field of liquid biopsy, expecting the technical challenges yet to be surmounted and future developmental directions.