Application of fecal microbiota transplantation in the treatment of malignant tumor
10.3760/cma.j.cn114452-20240708-00356
- VernacularTitle:粪菌移植在恶性肿瘤疾病治疗中的应用
- Author:
Yingjing FAN
1
;
Qi XIU
Author Information
1. 南方医科大学珠江医院检验医学部，广州 510280
- Keywords:
Neoplasms;
Fecal microbiota transplantation;
Intestinal flora;
Therapeutic
- From:
Chinese Journal of Laboratory Medicine
2024;47(11):1349-1354
- CountryChina
- Language:Chinese
-
Abstract:
Fecal Microbiota Transplantation (FMT) has achieved significant therapeutic effects in the treatment of various diseases such as Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease et al. Researches have shown that FMT may affect the occurrence and development of malignant tumors by remodeling the composition of patients′ intestinal flora, which has potential therapeutic value. In recent years, key techniques of FMT such as washed microbiota transplantation, transendoscopic enteral tubing, spore transplantation, and manually prepared transplantation, provide more possibilities for diseases treatment of FMT. This review introduces the development status of FMT, the pivotal techniques of FMT, and summarizes the applicational advantages and disadvantages. We also focus on the applied researches of FMT in the treatment of malignant tumor diseases, such as adjuvant immunotherapy, chemotherapy, surgical treatment and endocrine therapy, so as to provide theoretical basis for the future clinical application of FMT in this field.
