Research progress on senescence-associated secretory phenotypes in idiopathic pulmonary fibrosis

VernacularTitle:衰老相关分泌表型在特发性肺纤维化中的研究进展
Author: Lijuan HU ¹ ; Ruoyu LIU ; Yun ZHOU ; Yongtong CAO
Author Information

1. 北京协和医学院研究生院，北京　100730
Keywords: Pulmonary fibrosis; Idiopathic pulmonary fibrosis; Senescence-related secretory phenotype; Senescence; Biomarkers
From: Chinese Journal of Laboratory Medicine 2024;47(10):1215-1224
CountryChina
Language:Chinese
Abstract: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease that occurs mostly in the middle-aged and eldly people, with a short median survival and cannot be cured, and the etiology is still unclear. Currently, it is believed that the pathogenesis is related to cellular aging, and abnormal cellular aging leads to the failure of damaged alveolar epithelial cells that cannot be repaired normally, which promotes the occurrence of pulmonary fibrosis. Senescence-associated secretory phenotype (SASP), SASP affects pulmonary fibrosis through different signaling pathways in IPF patients, and this article reviews the expression level and mechanism of existing SASP in IPF patients.